Aleid Abdulsalam Mohammed, Alyabis Nouf Abdullah, Aldanyowi Saud Nayef, Albinsaad Loai Saleh, AlAidarous Hasan Ali, Aleid Zainab Mohammed, AlMutair Abbas Saleh
Department of Surgery, Medical College, King Faisal University, Hofuf, Ahsa, KSA.
Department of Surgery and Medicine, College of Medicine, Alfaisal University, Riyadh, KSA.
J Taibah Univ Med Sci. 2025 Feb 25;20(1):120-128. doi: 10.1016/j.jtumed.2025.01.002. eCollection 2025 Feb.
Chronic plantar fasciitis (CPF) is a degenerative condition causing persistent heel pain, making clinical management challenging. Among treatment options, the comparative effectiveness of platelet-rich plasma (PRP) and corticosteroid injections (CSIs) remains unclear. This systematic review and meta-analysis evaluate their impact on pain relief and functional improvement.
Following PRISMA guidelines, this review analyzed eight studies involving 599 participants. Pain and function were assessed using the Visual Analog Scale (VAS) and the American Orthopaedic Foot & Ankle Society (AOFAS) score. Study quality was evaluated using the Risk of Bias 2 tool, and both common- and random-effects models were applied.
Pain relief results were mixed. The common-effects model favored PRP (MD = -0.7166), but the random-effects model showed no significant difference (MD = 0.4657). For functional improvement, both models indicated PRP as superior (AOFAS score: MD = 16.13, 95% CI [14.70, 17.55]), with moderate variability (I² = 48.7%).
PRP shows promise in improving function and potentially providing better pain relief compared to CSIs for CPF. While study variability requires careful interpretation, PRP's functional benefits support its potential as a valuable treatment. Further research with standardized protocols and diverse populations is needed to confirm its clinical effectiveness.
慢性足底筋膜炎（CPF）是一种退行性疾病，会导致持续的足跟疼痛，给临床治疗带来挑战。在治疗选择中，富含血小板血浆（PRP）和皮质类固醇注射（CSI）的相对有效性仍不明确。本系统评价和荟萃分析评估了它们对缓解疼痛和功能改善的影响。
遵循PRISMA指南，本评价分析了八项涉及599名参与者的研究。使用视觉模拟量表（VAS）和美国矫形足踝协会（AOFAS）评分评估疼痛和功能。使用偏倚风险2工具评估研究质量，并应用固定效应模型和随机效应模型。
疼痛缓解结果不一。固定效应模型支持PRP（MD = -0.7166），但随机效应模型显示无显著差异（MD = 0.4657）。对于功能改善，两种模型均表明PRP更具优势（AOFAS评分：MD = 16.13，95%CI [14.70, 17.55]），异质性中等（I² = 48.7%）。
与CSI相比，PRP在改善CPF功能和可能提供更好的疼痛缓解方面显示出前景。虽然研究的变异性需要谨慎解读，但PRP的功能益处支持其作为一种有价值治疗方法的潜力。需要采用标准化方案并针对不同人群进行进一步研究，以证实其临床有效性。
