Chtioui Nesrine, Duval Christian, St-Pierre David H
Department of Exercice Science, University of Quebec in Montreal, Montreal, Quebec, Canada.
Research Center of the University Institute of Geriatrics of Montreal, Montreal, Quebec, Canada.
Clin Park Relat Disord. 2025 Feb 1;12:100301. doi: 10.1016/j.prdoa.2025.100301. eCollection 2025.
Alterations in the gut microbiota leading to intestinal inflammation and decreased levels of Short Chain Fatty Acids (SCFA) has been observed in Parkinson's disease (PD).
The aim of this study was to compare these factors between physically active and less active people with PD.
Stool, plasma samples and clinical data were collected from 35 people with PD (20 men and 15 women, mean age 66 years). Their level of physical activity was retrospectively assessed using the International Physical Activity Questionnaire (IPAQ). Participants were divided into two groups based on their physical activity level: Active and Inactive. Both SCFA and calprotectin, a marker of intestinal inflammation, were respectively measured by GC-MS and ELISA, according to standardized, validated protocols.
Age, disease stage (Hoen & Yahr) and Montreal Cognitive Assessments (MoCA) were similar between groups. Acetate, propionate, and butyrate levels were significantly higher in the Active group than in the Inactive group. In addition, fecal calprotectin was significantly lower in the Active group than in the Inactive group. The constipation values were significantly lower in the Active group.
Our results suggest that an active lifestyle with regular physical activity is beneficial in patients with PD, through increased production of SCFA by the gut microbiome, and reduced intestinal inflammation and constipation.
在帕金森病（PD）中已观察到肠道微生物群的改变会导致肠道炎症以及短链脂肪酸（SCFA）水平降低。
本研究的目的是比较PD患者中身体活动活跃和不活跃人群之间的这些因素。
从35名PD患者（20名男性和15名女性，平均年龄66岁）收集粪便、血浆样本和临床数据。使用国际体力活动问卷（IPAQ）对他们的体力活动水平进行回顾性评估。参与者根据体力活动水平分为两组：活跃组和不活跃组。根据标准化、经过验证的方案，分别通过气相色谱 - 质谱联用（GC - MS）和酶联免疫吸附测定（ELISA）测量SCFA和肠道炎症标志物钙卫蛋白。
两组之间的年龄、疾病阶段（霍恩和亚尔分期）和蒙特利尔认知评估（MoCA）相似。活跃组中乙酸盐、丙酸盐和丁酸盐水平显著高于不活跃组。此外，活跃组中粪便钙卫蛋白显著低于不活跃组。活跃组的便秘值显著更低。
我们的结果表明，对于PD患者，积极的生活方式和规律的体育活动是有益的，这是通过肠道微生物群增加SCFA的产生以及减少肠道炎症和便秘来实现的。
