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（-）-表儿茶素微生物代谢个体间变异性的特征。

Characterization of the Interindividual Variability Associated with the Microbial Metabolism of (-)-Epicatechin.

机构信息

Institute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, 2440 Boulevard Hochelaga, Québec, Quebec, Canada G1V 0A6.

Nutrition, Health and Society Centre (NUTRISS), INAF, Laval University, 2440 Boulevard Hochelaga, Québec, Quebec, Canada G1V 0A6.

出版信息

J Agric Food Chem. 2023 Sep 20;71(37):13814-13827. doi: 10.1021/acs.jafc.3c05491. Epub 2023 Sep 8.

DOI:10.1021/acs.jafc.3c05491
PMID:37683128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10516121/
Abstract

Although the relationship between gut microbiota and flavan-3-ol metabolism differs greatly between individuals, the specific metabolic profiles, known as metabotypes, have not yet been clearly defined. In this study, fecal batch fermentations of 34 healthy donors inoculated with (-)-epicatechin were stratified into groups based on their conversion rate of (-)-epicatechin and their quali-quantitative metabolic profile. Fast and slow converters of (-)-epicatechin, high producers of 1-(3'-hydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol (3-HPP-2-ol) and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (3,4-DHPVL) were identified. Fecal microbiota analysis revealed that fast conversion of (-)-epicatechin was associated with short-chain fatty acid (SCFA)-producing bacteria, such as spp. and spp., and higher levels of acetate, propionate, butyrate, and valerate were observed for fast converters. Other bacteria were associated with the conversion of 1-(3',4'-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol into 3-HPP-2-ol ( UCG-010 spp.) and 3,4-DHPVL (). Such stratification sheds light on the mechanisms of action underlying the high interindividual variability associated with the health benefits of flavan-3-ols.

摘要

尽管肠道微生物群和黄烷-3-醇代谢之间的关系在个体之间有很大差异，但特定的代谢特征（称为代谢类型）尚未明确界定。在这项研究中，将 34 名健康供体的粪便分批发酵，根据（-）-表儿茶素的转化率及其定性和定量代谢特征进行分组。确定了（-）-表儿茶素的快速和慢速转化体、1-（3'-羟基苯基）-3-（2″、4″、6″-三羟基苯基）-2-丙醇（3-HPP-2-ol）和 5-（3'、4'-二羟基苯基）-γ-戊内酯（3,4-DHPVL）的高产生体。粪便微生物群分析显示，（-）-表儿茶素的快速转化与短链脂肪酸（SCFA）产生细菌有关，例如 spp. 和 spp.，并且快速转化体中观察到乙酸盐、丙酸盐、丁酸盐和戊酸盐水平较高。其他细菌与 1-（3'、4'-二羟基苯基）-3-（2″、4″、6″-三羟基苯基）-2-丙醇转化为 3-HPP-2-ol（UCG-010 spp.）和 3,4-DHPVL（）有关。这种分层揭示了与黄烷-3-醇的健康益处相关的个体间高度变异性的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/6fd360a23ef0/jf3c05491_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/3acb493d2e8e/jf3c05491_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/34f5faef1cb0/jf3c05491_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/0e877be5b0cb/jf3c05491_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/50368545ed7c/jf3c05491_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/b63c6134a72a/jf3c05491_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/6c6d8a1d3a0f/jf3c05491_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/6fd360a23ef0/jf3c05491_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/3acb493d2e8e/jf3c05491_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/34f5faef1cb0/jf3c05491_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/0e877be5b0cb/jf3c05491_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/50368545ed7c/jf3c05491_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/b63c6134a72a/jf3c05491_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/6c6d8a1d3a0f/jf3c05491_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc54/10516121/6fd360a23ef0/jf3c05491_0008.jpg

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