Gosney J R
J Pathol. 1985 May;146(1):59-64. doi: 10.1002/path.1711460107.
Continuous exposure of adult male Wistar albino rats to a barometric pressure of 380 mm Hg (equivalent to an altitude of 5500 m) for 28 days causes a marked increase in adrenal gland weight due to hyperplasia of both adrenal cortex and medulla. The size of the cortical and medullary components of the gland relative to each other is unaffected; in both hypoxic and control animals the cortex occupies approximately 85 per cent of the overall volume of the gland. Cortical hyperplasia is consistent with the elevated levels of ACTH which have previously been shown to occur during hypoxia. Medullary hyperplasia under such conditions presumably reflects a continuing increased requirement for catecholamines in an hypoxic environment. The morphology of these adrenal medullae bears a striking structural resemblance to some phaeochromocytomata. Adrenal medullary hyperplasia does not appear to have been described previously under such conditions and may be an important effect of prolonged severe hypoxia.
成年雄性Wistar白化大鼠持续暴露于380毫米汞柱的气压（相当于海拔5500米）下28天，会导致肾上腺重量显著增加，这是由于肾上腺皮质和髓质均增生所致。腺体皮质和髓质成分的相对大小未受影响；在缺氧动物和对照动物中，皮质均约占腺体总体积的85%。皮质增生与先前已证实在缺氧期间出现的促肾上腺皮质激素（ACTH）水平升高相一致。在这种情况下，髓质增生大概反映了在缺氧环境中对儿茶酚胺的持续需求增加。这些肾上腺髓质的形态与某些嗜铬细胞瘤在结构上有惊人的相似之处。肾上腺髓质增生在这种情况下似乎以前未被描述过，可能是长期严重缺氧的一个重要影响。
