McConnochie K M, Mark J D, McBride J T, Hall W J, Brooks J G, Klein S J, Miller R L, McInerny T K, Nazarian L F, MacWhinney J B
J Pediatr. 1985 Jul;107(1):54-8. doi: 10.1016/s0022-3476(85)80614-4.
Concern about the long-term sequelae of bronchiolitis has been raised through studies of children hospitalized for bronchiolitis, but the long-term sequelae of mild bronchiolitis have not been studied. We assessed the hypothesis that 25 children with mild bronchiolitis (index subjects) were at greater risk for abnormalities of pulmonary function or airway reactivity to cold air between the ages of 8 and 12 years than were randomly selected, matched controls. There were no consistent differences in pulmonary function or airway reactivity between index and control groups. Airway hyperreactivity was found in five control subjects and three index subjects, and all children with symptomatic asthma were identified by cold air challenge. Our data suggest that children with a history of mild bronchiolitis are not at increased risk between ages 8 and 12 years for airway hyperreactivity or for abnormalities in pulmonary function.
通过对因细支气管炎住院的儿童进行研究，人们对细支气管炎的长期后遗症表示担忧，但轻度细支气管炎的长期后遗症尚未得到研究。我们评估了这样一个假设：25名患有轻度细支气管炎的儿童（索引对象）在8至12岁之间出现肺功能异常或气道对冷空气反应性异常的风险，比随机选择的匹配对照组儿童更高。索引组和对照组在肺功能或气道反应性方面没有一致的差异。在5名对照对象和3名索引对象中发现了气道高反应性，所有有症状性哮喘的儿童均通过冷空气激发试验得以识别。我们的数据表明，有轻度细支气管炎病史的儿童在8至12岁之间出现气道高反应性或肺功能异常的风险并未增加。
