白蛋白对离体大鼠肝细胞摄取磺溴酞的影响。

The effect of albumin on the uptake of bromosulfophthalein by isolated rat hepatocytes.

作者信息

Mizuma T, Horie T, Awazu S

出版信息

J Pharmacobiodyn. 1985 Feb;8(2):90-4. doi: 10.1248/bpb1978.8.90.

DOI:10.1248/bpb1978.8.90

Abstract

The initial rate of uptake of bromosulfophthalein (BSP) by isolated rat hepatocytes analyzed as a function of the unbound concentration of BSP was greater in the presence of albumin than in its absence, though the presence of albumin in the medium apparently decreased the uptake of BSP by hepatocytes analyzed as a function of the total concentration of BSP. This suggests that the uptake of BSP by isolated rat hepatocytes in the presence of albumin is not only dependent on the unbound concentration of BSP, but also is driven by the bound fraction of BSP.

摘要

将分离的大鼠肝细胞摄取磺溴酞钠（BSP）的初始速率作为BSP未结合浓度的函数进行分析时，白蛋白存在时的摄取速率高于不存在时，尽管培养基中白蛋白的存在明显降低了将肝细胞摄取BSP作为BSP总浓度函数时的摄取量。这表明在白蛋白存在下，分离的大鼠肝细胞摄取BSP不仅取决于BSP的未结合浓度，还受到BSP结合部分的驱动。