Sapmaz Mehmet Alican, Polat Murat, Erbey Sait, Eroglu Omer Osman, Kahyaoglu Inci
Obstetrics and Gynecology Clinic, Etlik City Hospital, 06170 Ankara, Turkey.
J Clin Med. 2025 Feb 25;14(5):1527. doi: 10.3390/jcm14051527.
Vernix caseosa is a natural protective barrier with moisturizing, wound healing, and antioxidant properties. This study aimed to evaluate the effects of vernix caseosa on skin pigmentation and wound healing in cesarean section incisions. This randomized, double-blind, placebo-controlled trial was conducted at Ankara Etlik City Hospital, Gynecology and Obstetrics Clinic. A total of 210 first-time cesarean section patients were included. Vernix caseosa, collected from newborns, was applied to the incision site in half of the participants, while the other half received a placebo. Scar assessment was performed using the Manchester Scar Scale and the Patient and Observer Scar Assessment Scale (POSAS). The vernix group showed significantly lower Manchester Scar Scale scores (9.00 ± 2.07 vs. 12.60 ± 2.72, < 0.001) and POSAS total scores (53.57 ± 20.48 vs. 89.60 ± 26.54, < 0.001) compared to the control group. These results suggest that vernix caseosa accelerates wound healing and improves cosmetic outcomes. Vernix caseosa emerges as a natural, effective, and low-cost method to promote wound healing in cesarean section incisions. Its medical and cosmetic benefits support its use in postoperative care. Future studies could further validate these findings in broader populations and explore additional clinical applications.
胎脂是一种具有保湿、伤口愈合和抗氧化特性的天然保护屏障。本研究旨在评估胎脂对剖宫产切口皮肤色素沉着和伤口愈合的影响。这项随机、双盲、安慰剂对照试验在安卡拉埃特利克市立医院妇产科诊所进行。共纳入210例首次剖宫产患者。将从新生儿身上收集的胎脂应用于一半参与者的切口部位，而另一半接受安慰剂。使用曼彻斯特瘢痕量表和患者及观察者瘢痕评估量表（POSAS）进行瘢痕评估。与对照组相比，胎脂组的曼彻斯特瘢痕量表评分（9.00±2.07 vs. 12.60±2.72，<0.001）和POSAS总分（53.57±20.48 vs. 89.60±26.54，<0.001）显著更低。这些结果表明，胎脂可加速伤口愈合并改善美容效果。胎脂成为促进剖宫产切口伤口愈合的一种天然、有效且低成本的方法。其医学和美容益处支持其在术后护理中的应用。未来的研究可以在更广泛的人群中进一步验证这些发现，并探索其他临床应用。
