Pernes J M, Angel C Y, Brenot P, Bruneval P, Camilleri J P, Gaux J C
J Radiol. 1985 Mar;66(3):225-31.
The effects of argon laser radiation of human atheroma were studied in vitro. Lesions produced were craters from total tissue volatilization surrounded by a thin zone of coagulation. The degree of tissue destruction was related to the energy used and the direction of the laser beam in relation to the atheromatous stenotic lesion. These findings confirm that it is possible to destroy the atheroma under controlled conditions, but at the non-negligible risk of perforation. By allowing visual control, the angioscope should ensure increased safety in use and provide hope for future applications of this method by the percutaneous route in the treatment of established atheromatous disease.
对人体动脉粥样硬化进行了氩激光辐射的体外研究。产生的病变是因组织完全挥发形成的凹坑，周围有一薄层凝固区。组织破坏程度与所使用的能量以及激光束相对于动脉粥样硬化狭窄病变的方向有关。这些发现证实，在可控条件下有可能破坏动脉粥样硬化斑块，但存在不可忽视的穿孔风险。通过可视控制，血管内窥镜应能确保使用时提高安全性，并为该方法未来经皮途径应用于已确诊的动脉粥样硬化疾病治疗带来希望。
