Lenz H, Wullstein H K, Eichler J
Laryngol Rhinol Otol (Stuttg). 1976 Oct;55(10):794-803.
The macroscopical and lightmicroscopical findings at the mucosa of the hamster cheek pouch after irradiation with an Argon-Ionlaser (wave-length 0.488 mum, power 200 mW, beam diameter 0.5 mm, power density 100 W/cm2) are described immediately, 1; 2,5; 5 and 10 days after irradiation. The mucosa was exposed 10 sec, 30 sec, 1, 2, 5 and 10 min to the radiation. With growing laser dosis the lesions of the mucosa and the postoperative healing time increases.A clinically useful optimal mucosa lesion with a short healing duration (within 5-10 days) is obtained only by application of a low and a middle laser dosis. There are two kinds of mucosa destruction by laser: 1. The destruction can be producing a coagulation necrosis with subsequent unbloody sloughing, resulting in an ulcus with rapid healing by complete reepithelisation and a small amount of connective tissue. 2. An immediate destruction is obtained by carbonisation of tissue after application of a middle to high laser dosis resulting in an ulcus with slow healing and also complete reepithelisation and small connective tissue. The typical laser lesion consists of 3 zones: The carbonisation zone is surrounded by a small coagulation zone followed by a zone of granulation tissue including thrombs and necrosis of the vessel walls. The unbloody procedure is based on an occlusion of the vessels immediately during laser radiation and later on by thrombosis in the periphery of the lesions. The possible clinical applications are discussed.
描述了用氩离子激光（波长0.488μm，功率200mW，光束直径0.5mm，功率密度100W/cm²）照射仓鼠颊囊黏膜后，在照射后即刻、1天、2.5天、5天和10天的宏观和光学显微镜检查结果。黏膜分别暴露于辐射10秒、30秒、1分钟、2分钟、5分钟和10分钟。随着激光剂量增加，黏膜损伤及术后愈合时间延长。只有应用低剂量和中等剂量激光才能获得临床上有用的、愈合持续时间短（5 - 10天内）的最佳黏膜损伤。激光对黏膜有两种破坏方式：1. 破坏可产生凝固性坏死，随后无血脱落，形成溃疡，通过完全上皮再生和少量结缔组织快速愈合。2. 应用中等至高剂量激光后，组织碳化导致即刻破坏，形成溃疡，愈合缓慢，但也有完全上皮再生和少量结缔组织。典型的激光损伤由3个区域组成：碳化区被一个小的凝固区包围，接着是一个包括血栓和血管壁坏死的肉芽组织区。无血过程基于激光辐射期间血管立即闭塞，随后在损伤周边形成血栓。讨论了可能的临床应用。
