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作者信息

Marzouk Mahmoud, Adhoum Aymen, Ben Yedder Azza, Hammami Rabeb, Thamlaoui Saber, Baffoun Nader

机构信息

Department of Anaesthesia and Intensive Care, National Institute of Neurology of Tunis, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

出版信息

Tunis Med. 2025 Feb 5;103(2):270-275. doi: 10.62438/tunismed.v103i2.5020.

DOI:10.62438/tunismed.v103i2.5020

PMID:40096730

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12034352/

Abstract

INTRODUCTION

Acute kidney Injury (AKI) is the most frequent complication of septic shock. Bedside ultrasound measurement of the renal resistance index (RRI) is an interesting way of assessment of renal hemodynamics.

AIMS

To study the variability of RRI during septic shock and its correlation with the occurrence of AKI.

METHODS

This is a prospective observational study including patients in septic shock and on mechanical ventilation. Data collection was carried out between October 2022 and July 2023. RRI was measured during the first five days of shock.

RESULTS

Forty patients were enrolled in the study. Mean age was equal to 51 years ±13.4 and sex ratio was equal to 2.33. The mean RRI value was 0.704, with extremes ranging from 0.52 to 0.83. Patients were divided into two groups : AKI(+) and AKI (-). RRI in the group AKI (+) was higher than in the group AKI (-) (0.757 vs. 0.672; p=0.013). RRI predicted the occurrence of AKI, with an area under the ROC curve of 0.75 (p=0.007) and a cut-off value of 0.71 (specificity=64%, sensitivity=73%).

CONCLUSION

Assessment of RRI could be a useful technique of predicting the onset of AKI in association with the conventional markers. Its validation will guide management towards optimal renal protection in patients with septic shock.

摘要

引言

急性肾损伤（AKI）是感染性休克最常见的并发症。床边超声测量肾阻力指数（RRI）是评估肾血流动力学的一种有趣方法。

目的

研究感染性休克期间RRI的变异性及其与AKI发生的相关性。

方法

这是一项前瞻性观察性研究，纳入感染性休克且接受机械通气的患者。数据收集于2022年10月至2023年7月进行。在休克的前五天测量RRI。

结果

40名患者纳入研究。平均年龄为51岁±13.4，性别比为2.33。RRI的平均值为0.704，范围从0.52至0.83。患者分为两组：AKI（+）组和AKI（-）组。AKI（+）组的RRI高于AKI（-）组（0.757对0.672；p=0.013）。RRI可预测AKI的发生，ROC曲线下面积为0.75（p=0.007），截断值为0.71（特异性=64%，敏感性=73%）。