Hu Yixin, Li Zehui, Hao Chenlin, Lu Hao, Xing Yunfei, Liu Kexin, Jin Xiaohui, Wei Zhanyong
College of Veterinary Medicine, Henan Agriculture University, Zhengzhou, 450046, China; Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, 450046, China.
College of Veterinary Medicine, Henan Agriculture University, Zhengzhou, 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, 450046, China; Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, 450046, China.
Virol Sin. 2025 Apr;40(2):296-299. doi: 10.1016/j.virs.2025.03.003. Epub 2025 Mar 15.
• A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time. • The B cell epitope of PAstV5 capsid protein was identified for the first time. • The monoclonal antibody 6c6 had strong neutralizing activity against PAstV5. • The identified epitope formed an alpha spiral structure and located outside the three-dimensional structure of the protein.
• 首次制备了针对PAstV5衣壳蛋白的中和单克隆抗体。
• 首次鉴定了PAstV5衣壳蛋白的B细胞表位。
• 单克隆抗体6c6对PAstV5具有强大的中和活性。
• 鉴定出的表位形成α螺旋结构，位于该蛋白三维结构的外部。
