Malik Hizbullah, Amir Fatima, Jahan Zaib, Liaqat Usman, Andleeb Saadia, Bandyopadhyay Sulalit, Khan Niazi Muhammad Bilal
Department of Chemical Engineering, School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad 44000, Pakistan; Particle Engineering Centre, Department of Chemical Engineering, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Department of Chemical Engineering, School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad 44000, Pakistan.
Int J Pharm. 2025 Apr 15;674:125482. doi: 10.1016/j.ijpharm.2025.125482. Epub 2025 Mar 15.
Extensive fluid loss, tissue damage, and bacterial infection are some important aspects that need to be addressed for designing ideal burn wound dressings. Hydrogel-based dressings cater to most of these functions; additionally, the incorporation of metal oxide nanoparticles (NPs) provides antibacterial properties that enhance the performance of wound dressings. We report here for the first time, how by employing different shapes of ZnO NPs, viz quasi-spherical, floral, and rods; in hydrogels made of PVA - P(AMPS) (Poly (vinyl alcohol) (PVA) - Poly (2-Acrylamido-2-Methyl Propane Sulfonic Acid)) along with g-CN, one could correlate structure-property relationships to wound healing efficiency. The incorporation of g-C3N4 was to enhance the thermo-mechanical stability of hydrogel, Maximum tensile strength of the hydrogel was obtained for 150 mg of g-C3N4 incorporated hydrogels, same amount being used for other systems studied. The impact of the incorporation of different shapes and amounts of ZnO NPs on the hydrogels has been studied and our results show maximum swelling ability (∼110 %), high moisture retention capacity (>90 %), and moderate water vapor transmission rate (82 g/mh) for selected systems. Among these different shapes incorporated hydrogels, remarkable enhancement in tensile strength (76 %) was observed for quasi-spherical ZnO NPs incorporated hydrogels compared to bare. These hydrogels showed high cell viability (>70 %), high antibacterial activities against E. coli and S. aureus, and high wound healing efficiency (>80 %) in an in-vivo rat model, proving their potential to be used in wound dressing applications.
大量的体液流失、组织损伤和细菌感染是设计理想烧伤创面敷料时需要考虑的一些重要方面。水凝胶基敷料能够满足其中的大部分功能；此外，金属氧化物纳米颗粒（NPs）的加入赋予了抗菌性能，从而提高了伤口敷料的性能。我们首次在此报告，通过在由聚乙烯醇 - 聚（2 - 丙烯酰胺 - 2 - 甲基丙烷磺酸）（PVA - P(AMPS)）制成的水凝胶中加入不同形状的氧化锌纳米颗粒，即准球形、花状和棒状，并加入石墨相氮化碳（g - CN），如何将结构 - 性能关系与伤口愈合效率相关联。加入g - C3N4是为了提高水凝胶的热机械稳定性，对于加入150mg g - C3N4的水凝胶，获得了最大拉伸强度，其他研究体系也使用相同的量。研究了不同形状和数量的氧化锌纳米颗粒加入对水凝胶的影响，我们的结果表明，所选体系具有最大溶胀能力（约110%）、高保湿能力（>90%）和适度的水蒸气透过率（82g/mh）。在这些加入不同形状纳米颗粒的水凝胶中，与未添加的相比，加入准球形氧化锌纳米颗粒的水凝胶的拉伸强度显著提高（76%）。这些水凝胶在体内大鼠模型中显示出高细胞活力（>70%）、对大肠杆菌和金黄色葡萄球菌的高抗菌活性以及高伤口愈合效率（>80%），证明了它们在伤口敷料应用中的潜力。
