Aina Morenikeji, Baillon Fabien, Sescousse Romain, Sanchez-Ballester Noelia M, Begu Sylvie, Soulairol Ian, Sauceau Martial
RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013, Albi, France.
RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013, Albi, France.
Int J Pharm. 2025 Apr 15;674:125436. doi: 10.1016/j.ijpharm.2025.125436. Epub 2025 Mar 15.
Semi-Solid Extrusion 3D printing (SSE 3DP) has emerged as a promising technology for fabricating oral drug formulations, offering significant opportunities for personalized medicine and tailored therapeutic outcomes. SSE 3DP is particularly advantageous for producing soft and chewable drug products and is well-suited for formulations containing thermosensitive drugs due to its low-temperature printing process. Among various 3D printing techniques, SSE 3DP holds considerable potential for point-of-care applications, enabling the on-demand production of patient-specific dosage forms. Despite these advantages, SSE 3DP faces certain limitations that affect its overall development and widespread adoption. This review provides a comprehensive overview of SSE 3DP's fundamental principles, current applications, and future prospects in oral drug delivery. It also addresses the challenges and limitations associated with SSE 3DP and examines the current outlook of this technique in oral drug delivery applications. An example of such a challenge is the lack of a harmonized method for evaluating rheological properties. To address this issue, the review describes a methodology for obtaining information related to extrudability and shape fidelity from rheological properties. Overall, this review aims to highlight the transformative potential of SSE 3DP in the pharmaceutical landscape, paving the way for tailored, and patient-centric therapies.
半固体挤出3D打印（SSE 3DP）已成为一种用于制造口服药物制剂的有前景的技术，为个性化医疗和定制治疗效果提供了重大机遇。SSE 3DP在生产柔软且可咀嚼的药品方面具有特别优势，并且由于其低温打印过程，非常适合含有热敏药物的制剂。在各种3D打印技术中，SSE 3DP在即时护理应用方面具有相当大的潜力，能够按需生产针对患者的剂型。尽管有这些优点，但SSE 3DP面临某些限制，影响其整体发展和广泛应用。本综述全面概述了SSE 3DP在口服药物递送中的基本原理、当前应用和未来前景。它还讨论了与SSE 3DP相关的挑战和限制，并审视了该技术在口服药物递送应用中的当前前景。此类挑战的一个例子是缺乏评估流变学性质的统一方法。为解决这个问题，本综述描述了一种从流变学性质中获取与挤出性和形状保真度相关信息的方法。总体而言，本综述旨在突出SSE 3DP在制药领域的变革潜力，为定制化和以患者为中心的疗法铺平道路。
