Mardones L
Biomedical Sciences Research Laboratory, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción, Chile Research Centre of Biodiversity and Sustainable Environment (CIBAS). Universidad Católica de la Santísima Concepción, Concepción, Chile.
Vitam Horm. 2025;128:155-180. doi: 10.1016/bs.vh.2024.09.002. Epub 2024 Oct 22.
Vitamin C is a crucial water-soluble antioxidant and an essential cofactor for enzymes like proline and lysine hydroxylases, playing a vital role in cellular physiology. While sodium-dependent ascorbate co-transporters (SVCT1 and SVCT2) are pivotal for vitamin C absorption and bioavailability, dehydroascorbic acid transporters within the facilitative glucose transporter (GLUT) family complement these functions and are relevant in various cellular, tissue-specific, or pathological contexts. This review focuses on comparing the structural and functional characteristics of GLUTs involved in glucose, dehydroascorbic acid and other substrate transport. It also presents evidence of the physiological and pathophysiological roles of dehydroascorbic acid transporters. Improved understanding of these transporters has the potential to advance strategies for preventing, diagnosing, and treating prevalent diseases such as cancer.
维生素C是一种至关重要的水溶性抗氧化剂，也是脯氨酸和赖氨酸羟化酶等酶的必需辅助因子，在细胞生理中发挥着重要作用。虽然钠依赖性抗坏血酸共转运蛋白（SVCT1和SVCT2）对维生素C的吸收和生物利用至关重要，但促进性葡萄糖转运蛋白（GLUT）家族中的脱氢抗坏血酸转运蛋白补充了这些功能，并且在各种细胞、组织特异性或病理情况下都具有相关性。本综述着重比较参与葡萄糖、脱氢抗坏血酸和其他底物转运的GLUT的结构和功能特征。它还展示了脱氢抗坏血酸转运蛋白的生理和病理生理作用的证据。对这些转运蛋白的深入了解有可能推进预防、诊断和治疗癌症等常见疾病的策略。
