Ali S F, Peck E J
J Neurosci Res. 1985;13(4):497-507. doi: 10.1002/jnr.490130404.
Exposure of ovariectomized rats to estradiol-17-beta for 48-96 hr resulted in a dose-dependent reduction in the number but not the Kd of D-2 dopamine receptors of the anterior pituitary. No influence of estrogen was observed on dopamine or muscarinic acetylcholine receptors of caudate or hypothalamus. The dose-response relationship observed suggested that the influence of estrogen is directly on the pituitary, not secondary to the alteration of dopaminergic systems in the hypothalamus.
将去卵巢大鼠暴露于17-β-雌二醇48 - 96小时，导致垂体前叶D-2多巴胺受体数量呈剂量依赖性减少，但解离常数（Kd）未受影响。未观察到雌激素对尾状核或下丘脑的多巴胺或毒蕈碱型乙酰胆碱受体有影响。所观察到的剂量反应关系表明，雌激素的影响直接作用于垂体，而非继发于下丘脑多巴胺能系统的改变。
