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AAV vector engineering for human aorta transduction: becoming a smooth operator.

作者信息

Rapti Kleopatra, Grimm Dirk

机构信息

Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, Heidelberg University, BioQuant, Center for Integrative Infectious Diseases (CIID), 69120, Heidelberg, Germany.

German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), partner site Heidelberg, 69120, Heidelberg, Germany.

出版信息

Gene Ther. 2025 Mar 17. doi: 10.1038/s41434-025-00526-9.

DOI:10.1038/s41434-025-00526-9
PMID:40097612
Abstract
摘要

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本文引用的文献

1
AAV library screening identifies novel vector for efficient transduction of human aorta.腺相关病毒文库筛选鉴定出用于高效转导人主动脉的新型载体。
Gene Ther. 2025 Mar;32(2):154-162. doi: 10.1038/s41434-024-00511-8. Epub 2024 Dec 18.
2
Aortic aneurysm: pathophysiology and therapeutic options.主动脉瘤：病理生理学与治疗选择
MedComm (2020). 2024 Sep 7;5(9):e703. doi: 10.1002/mco2.703. eCollection 2024 Sep.
3
The state of technological advancement to address challenges in the manufacture of rAAV gene therapies.解决 rAAV 基因治疗制造挑战的技术进步状况。
Biotechnol Adv. 2024 Nov;76:108433. doi: 10.1016/j.biotechadv.2024.108433. Epub 2024 Aug 20.
4
Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity.AAV9 半乳糖结合的调制产生新型基因治疗载体，并预测糖基亲合力的物种间差异。
Hum Gene Ther. 2024 Sep;35(17-18):734-753. doi: 10.1089/hum.2024.050. Epub 2024 Aug 13.
5
Adeno-associated virus as a delivery vector for gene therapy of human diseases.腺相关病毒作为人类疾病基因治疗的递送载体。
Signal Transduct Target Ther. 2024 Apr 3;9(1):78. doi: 10.1038/s41392-024-01780-w.
6
Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease.利用基因组学鉴定主动脉疾病的新治疗靶点。
Arterioscler Thromb Vasc Biol. 2024 Feb;44(2):334-351. doi: 10.1161/ATVBAHA.123.318771. Epub 2023 Dec 14.
7
An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature.工程化腺相关病毒衣壳介导脑血管周细胞和平滑肌细胞的高效转导。
Hum Gene Ther. 2023 Aug;34(15-16):682-696. doi: 10.1089/hum.2022.211.
8
Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors.基因治疗策略治疗外周动脉疾病和腺相关病毒载体带来的新机遇。
Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):836-851. doi: 10.1161/ATVBAHA.122.318902. Epub 2023 Apr 27.
9
Ancestral library identifies conserved reprogrammable liver motif on AAV capsid.祖先文库鉴定 AAV 衣壳上保守的可重编程肝脏基序。
Cell Rep Med. 2022 Nov 15;3(11):100803. doi: 10.1016/j.xcrm.2022.100803. Epub 2022 Nov 2.
10
Stent-based delivery of AAV2 vectors encoding oxidation-resistant apoA1.基于支架的 AAV2 载体递送至氧化抗性 apoA1 编码。
Sci Rep. 2022 Mar 31;12(1):5464. doi: 10.1038/s41598-022-09524-y.