Geisler Peter, Wehrle Renate, Yassouridis Alexander, Ultsch Alfred, Wetter Thomas C, Schulz Hartmut
Center of Sleep Medicine, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Ethics Committee, Ludwigs-Maximilians-University, Munich, Germany.
J Sleep Res. 2025 Dec;34(6):e70039. doi: 10.1111/jsr.70039. Epub 2025 Mar 18.
The aim of the present study was to explore age-related sleep alterations in normal subjects whose sleep had been recorded for the first time 40.4 ± 4.8 years ago. For the follow-up polysomnography (3 nights) 15 participants (5 female, 10 male, age 56-74 years) were recruited. Recording conditions and sleep scoring were adapted to the previous study. In all older participants, the amount of slow-wave sleep and REM sleep was decreased, while stage 1 and wakefulness were increased. There was no significant change in stage 2 or in any of the additional REM sleep parameters (REM density, latency, number and duration of REM cycles). Sleep stage transition analysis showed a markedly reduced stability of SWS from young to older age. While none of the single sleep parameters showed intra-individual stability with age, a pattern analysis, which combined seven sleep parameters (sleep stages, total sleep time and REM density), showed that the concordance rate of the combined sleep parameters correlated significantly with the age at follow-up. The results of this longitudinal study over a period of about 40 years are largely consistent with those of cross-sectional studies. While the lack of significant correlation of the individual sleep parameters between the younger and older age groups did not allow for the identification of any of them as trait markers, the result of the pattern analysis, which combined a set of sleep parameters, indicates that the stability of the sleep structure decreases significantly in the age range between the late 50s and early 70s.
本研究的目的是探讨正常受试者与年龄相关的睡眠变化，这些受试者的睡眠首次记录于40.4±4.8年前。为进行随访多导睡眠图检查（3晚），招募了15名参与者（5名女性，10名男性，年龄56 - 74岁）。记录条件和睡眠评分与之前的研究一致。在所有老年参与者中，慢波睡眠和快速眼动睡眠量减少，而1期睡眠和清醒时间增加。2期睡眠或任何其他快速眼动睡眠参数（快速眼动密度、潜伏期、快速眼动周期的数量和持续时间）均无显著变化。睡眠阶段转换分析显示，从年轻到老年，慢波睡眠的稳定性显著降低。虽然没有单个睡眠参数显示出随年龄的个体内稳定性，但一项结合了七个睡眠参数（睡眠阶段、总睡眠时间和快速眼动密度）的模式分析表明，组合睡眠参数的一致性率与随访时的年龄显著相关。这项长达约40年的纵向研究结果在很大程度上与横断面研究结果一致。虽然年轻和老年组之间个体睡眠参数缺乏显著相关性，无法将其中任何一个确定为特征标记，但结合一组睡眠参数的模式分析结果表明，在50多岁后期到70岁初期的年龄范围内，睡眠结构的稳定性显著下降。
