Zhu Zhaowei, Hua Yanming, Wu Jianta, Mei Jianfeng
Graduate School, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People's Republic of China.
Department of General Surgery, The General Surgery of Lanxi People's Hospital, Jinhua, Zhejiang, 321100, People's Republic of China.
Cancer Manag Res. 2025 Mar 13;17:577-587. doi: 10.2147/CMAR.S493015. eCollection 2025.
This study aimed to investigate the relationship between the expression of mucin (MUC) and JADE family PHD finger factor 1 (JADE1) and (HP) infection as well as depth of tumor invasion in gastric cancer.
According to the results of immunohistochemical staining, 132 gastric cancer patients diagnosed and treated in our hospital from March 2018 to May 2019 were divided into MUC2 negative group (n=43), MUC2 positive group (n=89), JADE1 negative group (n=36) and JADE1 positive group (n=96). The relationship between MUC2 and JADE1 expression and clinicopathological features of gastric cancer was analyzed. The diagnostic value of MUC2 and JADE1 alone or in combination in gastric cancer was analyzed using ROC curve.
The MUC2 and JADE1 expressions in gastric cancer tissues was increased (P<0.05). MUC2 and JADE1 expressions were related to different tumor size, differentiation degree, HP infection, lymph node metastasis, depth of tumor invasion and Lauren classification (P<0.05). Kaplan-Meier survival analysis showed that the survival rate of patients with negative expression of MUC2 and JADE1 was significantly lower than that of patients with positive expression of MUC2 and JADE1 (P<0.05). The area under the curve, sensitivity and specificity of MUC2 alone, JADE1 alone and the two combined in detection of gastric cancer was 0.774, 72.46% and 80.03%, 0.796, 82.14% and 76.48%, and 0.918, 91.34% and 89.57%, respectively.
The expressions of MUC2 and JADE1 in gastric cancer tissues were significantly increased, and their expressions were associated with tumor size, differentiation degree, HP infection, lymph node metastasis, depth of tumor infiltration, Lauren's staging. The combined detection of the two has a high value in the diagnosis of gastric cancer. Analysis of the relationship between MUC2 and JADE1 expression and HP infection is helpful for clinical medical staff to effectively evaluate the condition of patients.
本研究旨在探讨黏蛋白（MUC）和JADE家族PHD指蛋白因子1（JADE1）的表达与幽门螺杆菌（HP）感染以及胃癌肿瘤浸润深度之间的关系。
根据免疫组化染色结果，将2018年3月至2019年5月在我院诊断并治疗的132例胃癌患者分为MUC2阴性组（n = 43）、MUC2阳性组（n = 89）、JADE1阴性组（n = 36）和JADE1阳性组（n = 96）。分析MUC2和JADE1表达与胃癌临床病理特征之间的关系。采用受试者工作特征（ROC）曲线分析MUC2和JADE1单独或联合检测在胃癌中的诊断价值。
胃癌组织中MUC2和JADE1的表达升高（P < 0.05）。MUC2和JADE1的表达与不同的肿瘤大小、分化程度、HP感染、淋巴结转移、肿瘤浸润深度和Lauren分类相关（P < 0.05）。Kaplan-Meier生存分析显示，MUC2和JADE1阴性表达患者的生存率显著低于MUC2和JADE1阳性表达患者（P < 0.05）。MUC2单独检测、JADE1单独检测以及二者联合检测在胃癌诊断中的曲线下面积、灵敏度和特异度分别为0.774、72.46%和80.03%，0.796、82.14%和76.48%，以及0.918、91.34%和89.57%。
胃癌组织中MUC2和JADE1的表达显著升高，其表达与肿瘤大小、分化程度、HP感染、淋巴结转移、肿瘤浸润深度、Lauren分期相关。二者联合检测在胃癌诊断中具有较高价值。分析MUC2和JADE1表达与HP感染之间的关系有助于临床医务人员有效评估患者病情。
