Yim Wai Yen, Li Chenghao, Tong Fuqiang, Hou Jincheng, Chen Yuqi, Liu Zongtao, Wang Zihao, Geng Bingchuan, Wang Yixuan, Dong Nianguo
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.
Front Immunol. 2025 Mar 3;16:1556057. doi: 10.3389/fimmu.2025.1556057. eCollection 2025.
The innate and adaptive immune systems are intricately regulated by the circadian clock machinery. Recent clinical investigations have shed light on the influence of timing in organ procurement and transplantation on graft survival. In this review, we explore various mechanisms of immunological functions associated with the steps involved in organ transplantation, spanning from surgical harvesting to reperfusion and linking to the circadian rhythm. A deeper understanding of these processes has the potential to extend the principles of chrono-immunotherapy to the realm of organ transplantation, with the aim of enhancing graft durability and improving patient outcomes. This review concludes with some perspectives on future directions in this exciting and still evolving field of research.
先天性和适应性免疫系统受到生物钟机制的复杂调控。近期的临床研究揭示了器官获取和移植的时间安排对移植物存活的影响。在本综述中，我们探讨了与器官移植各个步骤相关的免疫功能的多种机制，从手术摘取到再灌注，并与昼夜节律相联系。对这些过程的更深入理解有可能将时辰免疫治疗的原则扩展到器官移植领域，以提高移植物的耐久性并改善患者预后。本综述最后对这个令人兴奋且仍在不断发展的研究领域的未来方向提出了一些观点。
