Yamakado T, Oonishi N, Nakano T, Takezawa H
Jpn Circ J. 1985 Apr;49(4):415-21. doi: 10.1253/jcj.49.415.
Twelve patients with uncomplicated systemic hypertension were treated with nifedipine (30 mg/day) and diltiazem (180 mg/day) for 1 month each, and performed two stage (50 watt and 100 watt) of bicycle ergometer exercise before and after each period of administration. Both drugs produced significant reduction in systolic and diastolic blood pressure at rest and during exercise, while the mean values of systolic blood pressure tended to be less with nifedipine than with diltiazem. Nifedipine caused a nonsignificant increase in heart rate at rest and during exercise, but diltiazem significantly decreased it at rest and during exercise. Cardiac output was significantly increased at rest and during mild exercise (50 watt), but not during more strenuous exercise (100 watt) with both drugs. Thus, different actions in arterial vasodilation and chronotropism between nifedipine and diltiazem in usual clinical doses were noted. However, nifedipine and diltiazem may be effective in hypertensive patients, probably with left ventricular dysfunction, because both drugs reduced systemic blood pressure even during exercise with simultaneous increase in cardiac output at rest and during mild exercise.
12例单纯性系统性高血压患者分别接受硝苯地平（30毫克/天）和地尔硫䓬（180毫克/天）治疗，各为期1个月，并在每次给药前后进行两阶段（50瓦和100瓦）的自行车测力计运动。两种药物均使静息和运动时的收缩压和舒张压显著降低，而硝苯地平治疗时收缩压的平均值往往低于地尔硫䓬。硝苯地平使静息和运动时的心率出现不显著的增加，但地尔硫䓬使静息和运动时的心率显著降低。两种药物均使静息和轻度运动（50瓦）时的心输出量显著增加，但在剧烈运动（100瓦）时则未增加。因此，观察到硝苯地平和地尔硫䓬在常用临床剂量下对动脉血管舒张和变时性有不同作用。然而，硝苯地平和地尔硫䓬可能对可能伴有左心室功能障碍的高血压患者有效，因为两种药物即使在运动期间也能降低全身血压，同时使静息和轻度运动时的心输出量增加。
