Kotake T, Kiyohara H
Jpn J Clin Oncol. 1985 Apr;15 Suppl 1:201-10.
Three hundred seventy-two clinical cases of multiple primary cancers (MPCs) involving bladder cancer (reported in the Japanese literature and including 36 of our own cases) and 376 autopsy cases (collected from the tables of the Annuals of Pathological Autopsy Cases in Japan from 1974 to 1981), were analyzed. Of the clinical cases studied, 299 patients were males and 73 females, and their average age was 65.7 years. In the 342 cases having only two primary cancers (PC), the two most common cancers associated with bladder cancer were cancer of the stomach (27.4%) and of the prostate (15.3%) in the males, and cancer of the cervix (27.9%) and of the stomach (16.2%) in the females. In the 119 cases in which the interval was known, the two PC were synchronous in 58 cases and metachronous in 61. In most cases of bladder cancer associated with other urological cancers (85.2%) the two were synchronous. In the females with metachronous cancers, bladder cancer frequently occurred as the second cancer after treatment of cervical or breast cancer. In autopsy cases, the ratio of MPC cases to the total number of cancer cases was 5.2%, and the ratios of MPC cases including bladder cancer to the total number of MPC cases and bladder cancer cases were 5.7% and 15.9%, respectively. The results of a study on organ association between cancer of the urinary bladder and of other organs were almost the same as those in the clinical study except for a lower frequency in other urogenital organs. In an epidemiological analysis of our own cases, the risk of MPC associated with bladder cancer was found to be highest in the stomach, the prostate, the larynx, and the liver. A significant value for the relative risk of a second cancer in another organ following bladder cancer was observed only for the prostate.
分析了372例涉及膀胱癌的多原发性癌（MPC）临床病例（报道于日本文献，包括我们自己的36例病例）以及376例尸检病例（从1974年至1981年的《日本病理尸检病例年鉴》表格中收集）。在所研究的临床病例中，男性患者299例，女性患者73例，平均年龄为65.7岁。在仅患有两种原发性癌（PC）的342例病例中，与膀胱癌相关的两种最常见癌症在男性中是胃癌（27.4%）和前列腺癌（15.3%），在女性中是宫颈癌（27.9%）和胃癌（16.2%）。在已知间隔时间的119例病例中，两种PC为同时性的有58例，异时性的有61例。在与其他泌尿系统癌症相关的大多数膀胱癌病例中（85.2%），两者是同时性的。在患有异时性癌症的女性中，膀胱癌常作为宫颈癌或乳腺癌治疗后的第二种癌症出现。在尸检病例中，MPC病例占癌症病例总数的比例为5.2%，包括膀胱癌的MPC病例占MPC病例总数和膀胱癌病例总数的比例分别为5.7%和15.9%。除了其他泌尿生殖器官的频率较低外，膀胱癌与其他器官之间器官关联的研究结果与临床研究结果几乎相同。在对我们自己病例的流行病学分析中，发现与膀胱癌相关的MPC风险在胃、前列腺、喉和肝脏中最高。仅在前列腺中观察到膀胱癌后另一器官发生第二种癌症的相对风险有显著值。
