Watanabe S, Kodama T, Shimosato Y, Arimoto H, Suemasu K
Jpn J Clin Oncol. 1985 Apr;15 Suppl 1:171-82.
The occurrence of multiple primary malignant neoplasms in 9,191 consecutive cases of primary gastrointestinal (GI) tract cancer from 1962 to 1981 at the National Cancer Center was analyzed. The person-years of the cases totaled 28,399.4: 185 second cancers were diagnosed clinically and 85 were first diagnosed at autopsy. The overall frequency was 2.01% for clinically recognizable cancers and 2.94% including those discovered at autopsy. The overall observed/expected ratio was 0.96 for clinical cancers and 1.33 including autopsy cases. However, a significant association between the first and second cancers was present in the oro-pharynx and esophagus; esophagus, stomach and colon; stomach and all other parts of the GI tract; and the colon and rectum. The mode of appearance was also analyzed to clarify the organ relationship.
对1962年至1981年期间国立癌症中心连续收治的9191例原发性胃肠道癌患者中多原发性恶性肿瘤的发生情况进行了分析。这些病例的人年数总计为28399.4：临床诊断出185例第二原发癌，尸检首次诊断出85例。临床可识别癌症的总体发生率为2.01%，包括尸检发现的癌症在内的总体发生率为2.94%。临床癌症的总体观察/预期比值为0.96，包括尸检病例在内为1.33。然而，口咽与食管、食管与胃和结肠、胃与胃肠道的所有其他部位以及结肠与直肠之间的第一原发癌和第二原发癌存在显著关联。还分析了出现方式以阐明器官关系。
