Nagura E, Kawashima K, Yamada K
Jpn J Clin Oncol. 1985 Apr;15 Suppl 1:211-22.
Two hundred and thirty-six cases of multiple primary cancer associated with hematological malignancies, collected from 35 medical institutions in Japan, are reported. Based on the time interval between the first cancer and the second cancer, they were divided into three groups: synchronous cancer (94 cases), metachronous cancer subsequent to hematological malignancy (61 cases) and metachronous hematological malignancy subsequent to carcinoma (76 cases). The most common initial cancers were acute leukemia (including atypical leukemia and erythroleukemia), non-Hodgkin's lymphoma, multiple myeloma and chronic myelogenous leukemia of the hematological malignancies, and gastric cancer of the carcinomas. Patients with cancer of the uterus and breast in the metachronous cancer group metachronously developed hematological malignancies more frequently than those in the synchronous cancer group. Multiple primary cancer was observed more frequently in men than in women both in the synchronous cancer group and in the group with metachronous cancer subsequent to hematological malignancies. Acute leukemia was the most frequent disease type in incidence among the metachronous hematological malignancies. This secondary acute leukemia was characterized by a mostly granulocytic nature, poor response to chemotherapy and poor prognosis.
本文报告了从日本35家医疗机构收集的236例与血液系统恶性肿瘤相关的多原发性癌病例。根据第一癌与第二癌之间的时间间隔，将其分为三组：同时性癌（94例）、血液系统恶性肿瘤继发的异时性癌（61例）和癌继发的异时性血液系统恶性肿瘤（76例）。血液系统恶性肿瘤中最常见的初始癌为急性白血病（包括非典型白血病和红白血病）、非霍奇金淋巴瘤、多发性骨髓瘤和慢性粒细胞白血病，癌中最常见的为胃癌。异时性癌组中子宫癌和乳腺癌患者异时性发生血液系统恶性肿瘤的频率高于同时性癌组。同时性癌组和血液系统恶性肿瘤继发的异时性癌组中，男性多原发性癌的发生率均高于女性。急性白血病是异时性血液系统恶性肿瘤中发病率最高的疾病类型。这种继发性急性白血病的特点主要为粒细胞性、化疗反应差和预后不良。
