Cui Jinwei, Ruan Shiye, Zhang Zhongyan, Wang Hailiang, Yan Qian, Chen Yubin, Yang Jiayu, Fang Jike, Wu Qianlong, Chen Sheng, Huang Shanzhou, Zhang Chuanzhao, Hou Baohua
South China University of Technology School of Medicine, Guangzhou, 51000, China.
Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China.
Discov Oncol. 2025 Mar 18;16(1):345. doi: 10.1007/s12672-025-02061-w.
NSUN7, an enzyme responsible for the RNA m5c modification, has been recognized as a valuable indicator for predicting and diagnosing an array of cancer. Nevertheless, there is still a scarcity of thorough analyses exploring its diagnostic, predictive, and immune system-related importance in various types of cancer.
We integrated multiple publicly available databases, including TCGA, TISIDB, TISCH2, and UALCAN, to comprehensively investigate the role of NSUN7 in pan-cancer across various omics data types. The research included examining survival rates, genetic mutations, immune cell presence in tumors, analyzing differences in gene expression, and studying individual cells, among other things.
NSUN7 expression showed an increase across 12 cancer types and a decrease in another 12 types. NSUN7 was discovered to be linked with enhanced survival rates in bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), pheochromocytoma and paraganglioma (PCPG), skin cutaneous melanoma (SKCM), and uveal melanoma (UVM).On the other hand, NSUN7 seemed to have a detrimental impact on the prognosis of glioblastoma multiforme/brain lower grade glioma (GBMLGG), adrenocortical carcinoma (ACC),acute myeloid leukemia (LAML), stomach adenocarcinoma (STAD), and brain lower grade glioma (LGG). Furthermore, our experimental validation confirmed the inhibitory effect of NSUN7 on proliferation of renal clear cell carcinoma while elucidating its specific part in blocking cell cycle progression.
The findings underscore the potential utility of NSUN7 as a valuable prognostic indicator for patients and offer insights into the mechanisms underlying cancer initiation and progression.
NSUN7是一种负责RNA m5c修饰的酶，已被认为是预测和诊断一系列癌症的重要指标。然而，对于其在各类癌症中的诊断、预测及免疫系统相关重要性，仍缺乏深入分析。
我们整合了多个公开可用的数据库，包括TCGA、TISIDB、TISCH2和UALCAN，以全面研究NSUN7在泛癌中跨多种组学数据类型的作用。该研究包括检查生存率、基因突变、肿瘤中免疫细胞的存在情况、分析基因表达差异以及研究单个细胞等。
NSUN7的表达在12种癌症类型中呈上升趋势，在另外12种类型中呈下降趋势。研究发现，NSUN7与膀胱尿路上皮癌（BLCA）、肾透明细胞癌（KIRC）、肾乳头状细胞癌（KIRP）、肺腺癌（LUAD）、嗜铬细胞瘤和副神经节瘤（PCPG）、皮肤黑色素瘤（SKCM）以及葡萄膜黑色素瘤（UVM）的生存率提高有关。另一方面，NSUN7似乎对多形性胶质母细胞瘤/低级别脑胶质瘤（GBMLGG）、肾上腺皮质癌（ACC）、急性髓系白血病（LAML）、胃腺癌（STAD）和低级别脑胶质瘤（LGG）的预后有不利影响。此外，我们的实验验证证实了NSUN7对肾透明细胞癌增殖的抑制作用，并阐明了其在阻断细胞周期进程中的具体作用。
这些发现强调了NSUN7作为患者重要预后指标的潜在效用，并为癌症发生和发展的潜在机制提供了见解。
