苯丙胺处理对3H-胸腺嘧啶核苷掺入发育中大鼠脑DNA的抑制作用。

Inhibition of 3H-thymidine incorporation into the DNA of developing rat brain by amphetamine treatment.

Béndek G, Hahn Z

Institute of Physiology, University Medical School, Pecs, Hungary.

Prog Neuropsychopharmacol. 1979;3(5-6):555-8. doi: 10.1016/0364-7722(79)90010-9.

Abstract

The incorporation of labelled thymidine into the brain of 10 day-old rats, used as the index of mitotic activity, was decreased two hours after administration of 20-40 mg/kg doses of amphetamine phosphate. 2. The entry of precursor from the blood to the brain tissue was not disturbed. 3. The observed elevation of plasma corticosterone levels did not appear to mediate the effect. 4. Changes in the normal balance of tissue norepinephrine and dopamine levels are considered as possible inhibitory factors in glial cell proliferation.

摘要

将标记的胸腺嘧啶核苷掺入10日龄大鼠的大脑中，以此作为有丝分裂活性的指标，在给予20 - 40毫克/千克剂量的磷酸苯丙胺两小时后，掺入量减少。2. 前体从血液进入脑组织的过程未受干扰。3. 观察到的血浆皮质酮水平升高似乎并未介导这种作用。4. 组织中去甲肾上腺素和多巴胺水平的正常平衡变化被认为是胶质细胞增殖的可能抑制因素。