胰岛素抵抗替代指标可能预测年轻非肥胖个体的高血压-高尿酸血症。
Insulin Resistance Surrogates May Predict HTN-HUA in Young, Non-Obese Individuals.
作者信息
Zuo Yu-Qiang, Gao Zhi-Hong, Yin Yu-Ling, Yang Xu, Guan Xing, Feng Ping-Yong
机构信息
Department of Physical Examination Center, The 2nd Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Physical Examination Center, The People's Hospital of Shijiazhuang City, Shijiazhuang, Hebei, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2024 Sep 28;17:3593-3601. doi: 10.2147/DMSO.S482184. eCollection 2024.
OBJECTIVE
To compare the associations of three surrogate markers of insulin resistance (IR) [glucose and triglycerides (TyG index), TyG index with BMI (TyG-BMI), and the ratio of triglycerides divided by HDL-C (TG/HDL-C)] with hypertensive patients (HTN) plus hyperuricemia (HUA) (HTN-HUA) in young, non-obese individuals.
METHODS
Data from a cross-sectional epidemiological study of an annual health check-up population aged younger than 66 years were used to calculate the three IR surrogate indexes. The association with HTN-HUA and insulin resistance surrogates was examined with multinomial logistic regression and a receiver operating characteristic (ROC) curve.
RESULTS
A total of 6952 participants were included, including 671 (9.65%) participants with HTN alone, 272 (3.91%) participants with HUA alone, and 62 (0.90%) participants with HTN and HUA. Binary multiple-logistic regression results showed that TG/HDL-C was significantly correlated with HTN, HUA, and HTN-HUA. Compared with the lowest quartile, the odds ratios (95% CI) of the highest quartile of TG/HDL-C for HTN-HUA were 3.462 (1.13810.530). TG/HDL-C and TyG-BMI had moderate discriminative abilities for HTN-HUA, and the area under the curve was 0.748 (0.6820.815), 0.746 (0.694~0.798).
CONCLUSION
Our study suggests that TG/HDL-C had a significant correlation with HTN-HUA and that TG/HDL-C had moderate discriminative abilities for HTN-HUA.
目的
比较胰岛素抵抗（IR）的三种替代标志物[血糖与甘油三酯（TyG指数）、TyG指数与体重指数（TyG-BMI）以及甘油三酯除以高密度脂蛋白胆固醇（HDL-C）的比值（TG/HDL-C）]与年轻、非肥胖个体中的高血压患者（HTN）合并高尿酸血症（HUA）（HTN-HUA）之间的关联。
方法
利用对66岁以下年度健康体检人群进行的横断面流行病学研究数据，计算这三种IR替代指标。采用多项逻辑回归和受试者工作特征（ROC）曲线研究与HTN-HUA和胰岛素抵抗替代指标之间的关联。
结果
共纳入6952名参与者，其中仅患有HTN的参与者671名（9.65%），仅患有HUA的参与者272名（3.91%），同时患有HTN和HUA的参与者62名（0.90%）。二元多逻辑回归结果显示，TG/HDL-C与HTN、HUA和HTN-HUA显著相关。与最低四分位数相比，TG/HDL-C最高四分位数对于HTN-HUA的比值比（95%CI）为3.462（1.13810.530）。TG/HDL-C和TyG-BMI对HTN-HUA具有中等判别能力，曲线下面积分别为0.748（0.6820.815）、0.746（0.694~0.798）。
结论
我们的研究表明，TG/HDL-C与HTN-HUA显著相关，且TG/HDL-C对HTN-HUA具有中等判别能力。
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