Coyle Christina M, Bustos Javier A, Del Brutto Oscar H, Garcia Hector H, Nash Theodore E, Rajshekhar Vedantam
Department of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York.
Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Perú.
Am J Trop Med Hyg. 2025 Mar 18;112(6):1187-1192. doi: 10.4269/ajtmh.24-0446. Print 2025 Jun 4.
Neurocysticercosis (NCC) is the most common helminthic infection of the human central nervous system (CNS), and a major cause of acquired epilepsy in most of the world. Although outcomes of NCC have been improved by advanced diagnostic tests, antiparasitic drugs, and appropriate anti-inflammatory treatment, little attention has been paid to calcified NCC. Calcification is a common outcome in NCC and carries increased risk for seizures and hippocampal atrophy/sclerosis. The pathophysiological mechanisms leading to calcification instead of complete resolution are basically unknown. Understanding the causes and mechanisms of calcification can lead to improved therapies aimed at reducing the likelihood of residual calcification or the underlying pathological mechanisms, after the resolution of parasitic lesions in the human CNS.
神经囊尾蚴病（NCC）是人类中枢神经系统（CNS）最常见的蠕虫感染，也是世界上大多数地区后天性癫痫的主要病因。尽管先进的诊断测试、抗寄生虫药物和适当的抗炎治疗已改善了NCC的治疗效果，但钙化性NCC却很少受到关注。钙化是NCC的常见结局，会增加癫痫发作和海马萎缩/硬化的风险。导致钙化而非完全消退的病理生理机制基本上尚不清楚。了解钙化的原因和机制可以带来更好的治疗方法，旨在降低人类中枢神经系统寄生虫病变消退后残留钙化或潜在病理机制的可能性。
