Holmes Terri L, Chabronova Alzbeta, Denning Chris, James Victoria, Peffers Mandy J, Smith James G W
Centre for Metabolic Health, Norwich Medical School, University of East Anglia, Norwich, Norfolk NR4 7UQ, UK.
Department of Musculoskeletal Ageing Science, University of Liverpool, Liverpool, UK.
Open Biol. 2025 Mar;15(3):240371. doi: 10.1098/rsob.240371. Epub 2025 Mar 19.
The small nucleolar RNA (snoRNA) SNORD116 is a small non-coding RNA of interest across multiple biomedical fields of research. Much of the investigation into SNORD116 has been undertaken in the context of the congenital disease Prader-Willi syndrome, wherein SNORD116 expression is lost. However, emerging evidence indicates wider roles in various disease and tissue contexts such as cellular growth, metabolism and signalling. Nevertheless, a conclusive mechanism of action for SNORD116 remains to be established. Here, we review the key findings from these investigations, with the aim of identifying common elements from which to elucidate potential targets and mechanisms of SNORD116. A key recurring element identified is disruption to the insulin/IGF-1 and PI3K/mTOR signalling pathways, contributing to many of the phenotypes associated with SNORD116 modulation explored in this review.
小核仁RNA（snoRNA）SNORD116是多个生物医学研究领域中备受关注的一种小非编码RNA。对SNORD116的许多研究都是在先天性疾病普拉德-威利综合征的背景下进行的，在该疾病中SNORD116的表达缺失。然而，新出现的证据表明它在各种疾病和组织环境中发挥着更广泛的作用，如细胞生长、代谢和信号传导。尽管如此，SNORD116的确切作用机制仍有待确定。在此，我们回顾了这些研究的关键发现，旨在找出共同要素，以阐明SNORD116的潜在靶点和作用机制。确定的一个反复出现的关键要素是胰岛素/胰岛素样生长因子-1（IGF-1）和磷脂酰肌醇-3激酶（PI3K）/哺乳动物雷帕霉素靶蛋白（mTOR）信号通路的破坏，这导致了本综述中探讨的许多与SNORD116调节相关的表型。
