从伊朗野外采集的人头虱（虱目：虱科）中新型谷氨酸门控氯离子通道突变的分子检测
Molecular detection of novel Glutamate-gated chloride channel mutations in field collected human head lice (Phthiraptera: Pediculidae) from Iran.
作者信息
Mansouri Vahid, Gholizadeh Saber
机构信息
Health and Biomedical Informatics Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Medical Entomology and Vector Control, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
出版信息
BMC Res Notes. 2025 Mar 18;18(1):115. doi: 10.1186/s13104-025-07176-5.
OBJECTIVE
Recently, insecticides such as ivermectin, which targets glutamate-gated chloride channel (GluCl) channels in the nervous system of invertebrates, have gained attention for the treatment of head lice. However, resistance to this insecticide threatens the effectiveness of head louse control programs.
RESULTS
Molecular bioinformatics sequence analysis revealed that the most common mutations were R37K and E50K with a frequency of 85.71%, followed by D93N (64.28%), M101R (35.71%), and R100Q (28.57%). These mutations are reported here for the first time. The identification of these novel mutations in head louse populations raises concerns about the potential emergence of ivermectin resistance. Further research is needed to explore the functional implications of these mutations and their impact on the effectiveness of insecticide treatments.
目的
最近，诸如伊维菌素这类作用于无脊椎动物神经系统中谷氨酸门控氯离子通道（GluCl）的杀虫剂，在头虱治疗方面受到了关注。然而，对这种杀虫剂的抗性威胁着头虱控制项目的有效性。
结果
分子生物信息学序列分析表明，最常见的突变是R37K和E50K，频率为85.71%，其次是D93N（64.28%）、M101R（35.71%）和R100Q（28.57%）。这些突变首次在此报道。头虱种群中这些新突变的发现引发了对伊维菌素抗性潜在出现的担忧。需要进一步研究来探索这些突变的功能意义及其对杀虫剂治疗效果的影响。
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