两样本孟德尔随机化分析确定了与颅内动脉瘤形成相关的脂质种类。

Two-Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation.

作者信息

Yan Junqing

机构信息

Nanxiang Branch of Ruijin Hospital, Shanghai, China.

出版信息

Brain Behav. 2025 Mar;15(3):e70435. doi: 10.1002/brb3.70435.

DOI:10.1002/brb3.70435

PMID:40103236

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11919785/

Abstract

OBJECTIVES

Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 lipid variants' impact on unruptured intracranial aneurysms (uIA).

MATERIALS AND METHODS

Utilizing GWAS data for lipids and uIAs, MR analyses were employed with pleiotropy, heterogeneity, and sensitivity tests. Reverse MR analyses were then conducted.

RESULTS

MR analyses revealed seven lipids associated with uIAs: TAG (51:3). SE (27:1/16:1), PC (18:2_18:2), TAG (48:1), TAG (48:2), and TAG (51:3) were identified as uIA risk factors, while SE (27:1/18:1) and SM (d34:0) exhibited protective effects. Reverse MR analysis showed no bidirectional causal relationships.

CONCLUSIONS

This study identifies specific lipid variants causally linked to uIAs, shedding light on their roles in IA formation. These findings contribute to future research on IA risk assessment and potential therapeutic interventions.

摘要

目的

颅内动脉瘤（IA）对健康构成重大风险，其形成涉及多种因素，包括脂质代谢，而以往研究仅关注标准脂质。本研究的目的是探讨179种脂质变体对未破裂颅内动脉瘤（uIA）的影响。

材料与方法

利用脂质和uIA的全基因组关联研究（GWAS）数据，采用多效性、异质性和敏感性检验的孟德尔随机化（MR）分析方法。然后进行反向MR分析。

结果

MR分析显示7种脂质与uIA相关：三酰甘油（TAG，51:3）、鞘脂（SE，27:1/16:1）、磷脂酰胆碱（PC，18:2_18:2）、三酰甘油（TAG，48:1）、三酰甘油（TAG，48:2）和三酰甘油（TAG，51:3）被确定为uIA的危险因素，而鞘脂（SE，27:1/18:1）和神经酰胺（SM，d34:0）具有保护作用。反向MR分析未显示双向因果关系。