Jalali Sediqeh
Department of Biology, Payam Noor University, Tehran, Iran.
ARYA Atheroscler. 2024;20(6):27-33. doi: 10.48305/arya.2024.42635.2961.
Liver X receptors (LXR) play an essential role in the regulation of cholesterol metabolism, and their activation increases ABCG5 and ABCG8 gene expression for the improvement of cholesterol excretion from the body during reverse cholesterol transport (RCT). The aim of this study was to investigate the effects of high-intensity interval (HIT) and low-intensity continuous (LIT) trainings on gene expression of these substances after a high-fat diet in Wistar rats.
Fifteen male Wistar rats were divided into 3 groups: control group (n = 5), HIT exercise group (n = 5), and LIT exercise group (n = 5). All groups were fed a high-fat diet for 13 weeks, and the HIT and LIT groups performed the specific training program. The expression of LXRβ, ABCG5, and ABCG8 genes was measured after the training period.
Data analysis showed significantly higher levels of LXRβ, ABCG5, and ABCG8 gene expression in the HIT and LIT groups compared to the control group (P ≤ 0.05).
HIT and LIT trainings after a high-fat diet have beneficial effects on RCT, preventing heart attacks. Additionally, HIT training may have a greater effect on cholesterol excretion during the reverse cholesterol transport mechanism than LIT.
肝脏X受体（LXR）在胆固醇代谢调节中起重要作用，其激活可增加ABCG5和ABCG8基因表达，以改善逆向胆固醇转运（RCT）过程中胆固醇从体内的排泄。本研究旨在探讨高脂饮食后高强度间歇训练（HIT）和低强度持续训练（LIT）对Wistar大鼠这些物质基因表达的影响。
15只雄性Wistar大鼠分为3组：对照组（n = 5）、HIT运动组（n = 5）和LIT运动组（n = 5）。所有组均给予高脂饮食13周，HIT组和LIT组进行特定训练方案。训练期结束后检测LXRβ、ABCG5和ABCG8基因的表达。
数据分析显示，与对照组相比，HIT组和LIT组中LXRβ、ABCG5和ABCG8基因表达水平显著更高（P≤0.05）。
高脂饮食后的HIT和LIT训练对RCT有有益影响，可预防心脏病发作。此外，在逆向胆固醇转运机制中，HIT训练对胆固醇排泄的影响可能比LIT更大。
