Mashayekhi Mahtab, Rezaei Mahdokht, Allami Abbas, Bazgir Narges, Mirzadeh Monirsadat, Aliakbari Shahin, Rahimi Ardali Kimia
Boali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
ARYA Atheroscler. 2024;20(6):34-42. doi: 10.48305/arya.2024.42494.2942.
ST-segment elevation myocardial infarction (STEMI) results from coronary artery blockage due to ruptured atherosclerotic plaque. Eosinophils play a dual role in STEMI, contributing to thrombus formation and tissue repair. This study investigates the association between eosinophil percentage, platelet counts, and in-hospital prognosis in STEMI patients.
A cross-sectional study was conducted from September 2019 to February 2020, including patients aged 18 and above with a STEMI diagnosis. In-hospital mortality, arrhythmia, and left ventricular ejection fraction (LVEF) were recorded. Demographic data, clinical manifestations, and laboratory investigations were collected. Data were analyzed using SPSS (version 25.0), with a P value of <0.05 considered significant.
The study included 100 STEMI patients with a mean age of 65±13.26 years; 75% were male. The mortality rate was 13%. A significant relationship was found between eosinophil percentage and mortality (p=0.032), and platelet count also correlated significantly with mortality (p=0.008). The association between eosinophil percentage and EF was significant (p<0.001). The area under the ROC curve was 0.705 (95% CI 0.605 - 0.792) for platelet counts and 0.679 (95% CI 0.577 - 0.770) for eosinophil percentage in differentiating live and expired patients.
Platelet count could be a significant prognostic indicator for in-hospital outcomes in STEMI patients, suggesting an increased risk of mortality. Additionally, there is a notable relationship between eosinophil percentage and ejection fraction (EF).
ST段抬高型心肌梗死（STEMI）是由动脉粥样硬化斑块破裂导致冠状动脉阻塞引起的。嗜酸性粒细胞在STEMI中发挥双重作用，有助于血栓形成和组织修复。本研究调查了STEMI患者嗜酸性粒细胞百分比、血小板计数与住院预后之间的关联。
于2019年9月至2020年2月进行了一项横断面研究，纳入年龄在18岁及以上且诊断为STEMI的患者。记录住院死亡率、心律失常和左心室射血分数（LVEF）。收集人口统计学数据、临床表现和实验室检查结果。使用SPSS（版本25.0）进行数据分析，P值<0.05被认为具有统计学意义。
该研究纳入了100例STEMI患者，平均年龄为65±13.26岁；75%为男性。死亡率为13%。发现嗜酸性粒细胞百分比与死亡率之间存在显著关系（p=0.032），血小板计数也与死亡率显著相关（p=0.008）。嗜酸性粒细胞百分比与EF之间的关联具有统计学意义（p<0.001）。在区分存活和死亡患者时，血小板计数的ROC曲线下面积为0.705（95%CI 0.605 - 0.792），嗜酸性粒细胞百分比的ROC曲线下面积为0.679（95%CI 0.577 - 0.77）。
血小板计数可能是STEMI患者住院结局的重要预后指标，提示死亡风险增加。此外，嗜酸性粒细胞百分比与射血分数（EF）之间存在显著关系。
