Firani Novi Khila, Hartanti Khoirunisah Dwi, Purnamasari Putri
Clinical Pathology Department, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Clinical Pathology Resident, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Int J Gen Med. 2022 Aug 23;15:6757-6763. doi: 10.2147/IJGM.S380659. eCollection 2022.
Acute myocardial infarction (AMI) is one of the leading causes of death in the world. Several hematological parameters are involved in AMI conditions and can be explored for their ability to predict in-hospital mortality. We evaluated hematological parameter value as predictors of in-hospital mortality in AMI patients.
Analytical observational study on AMI patients that admitted to Dr. Saiful Anwar Hospital, June-August 2021. Complete blood count was taken at the beginning of hospital admission. Patients with sepsis were excluded from the study. The research subjects were divided into two groups, survivor group and non-survivor group (in-hospital mortality). Hematological parameters as predictors of mortality were analyzed using the ROC curve and odds ratio.
Among 44 study subjects, 19 (43.18%) patients were in the non-survivor group and 25 (56.82%) patients were in the survivor group. Hematological parameters that can be predictors of mortality include leukocytes (AUC = 0.744; p = 0.006), neutrophils (AUC = 0.729; p = 0.010), eosinophils (AUC = 0.696; p = 0.028), and eosinophils/leukocytes ratio (AUC = 0.772; p = 0.012). The cut-off value for leukocytes was 13,725/μL (OR: 9), neutrophils was 12,008/μL (OR: 8.14), eosinophils was 58.3/μL (OR: 4.06), and eosinophil/leukocyte ratio was 0.0025 (OR: 4.41) with sensitivity 63.25%, 52.6%, 78.9%, and 63.2%, respectively, and specificity 84%, 88%, 52%, and 72%, respectively.
Leukocyte, neutrophils, eosinophils count and eosinophil/leukocyte ratio can help predict in-hospital mortality of AMI patients.
急性心肌梗死（AMI）是全球主要死因之一。多种血液学参数与AMI病情相关，可探究其预测院内死亡率的能力。我们评估了血液学参数值作为AMI患者院内死亡率的预测指标。
对2021年6月至8月入住赛义夫·安瓦尔博士医院的AMI患者进行分析性观察研究。入院时进行全血细胞计数。脓毒症患者被排除在研究之外。研究对象分为两组，存活组和非存活组（院内死亡）。使用ROC曲线和比值比分析作为死亡率预测指标的血液学参数。
在44名研究对象中，19名（43.18%）患者在非存活组，25名（56.82%）患者在存活组。可作为死亡率预测指标的血液学参数包括白细胞（AUC = 0.744；p = 0.006）、中性粒细胞（AUC = 0.729；p = 0.010）、嗜酸性粒细胞（AUC = 0.696；p = 0.028）以及嗜酸性粒细胞/白细胞比值（AUC = 0.772；p = 0.012）。白细胞的截断值为13,725/μL（OR：9），中性粒细胞为12,008/μL（OR：8.14），嗜酸性粒细胞为58.3/μL（OR：4.06），嗜酸性粒细胞/白细胞比值为0.0025（OR：4.41），敏感性分别为63.25%、52.6%、78.9%和63.2%，特异性分别为84%、88%、52%和72%。
白细胞、中性粒细胞、嗜酸性粒细胞计数及嗜酸性粒细胞/白细胞比值有助于预测AMI患者的院内死亡率。
