Li Xiaozhuo, Fang Kevin, Wang Fengping
School of Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming China.
Living Systems Institute University of Exeter Exeter UK.
Ibrain. 2025 Jan 4;11(1):59-73. doi: 10.1002/ibra.12189. eCollection 2025 Spring.
Parkinson's disease (PD) is a neurodegenerative disease characterized by degeneration of dopamine neurons in the substantia nigra pars compacta. The patient exhibits a series of motor symptoms, such as static tremors, which impair their capacity to take care for themselves in daily life. In the late stage, the patient is unable to walk independently and is bedridden for an extended period of time, reducing their quality of life significantly. So far, treatment methods for PD mainly include drug therapy and deep brain stimulation. Pharmacotherapy is aimed at increasing dopamine (DA) levels; however, the treatment effect is more pronounced in the short term, and there is no benefit in improvement in the overall progression of the disease. In recent years, novel therapeutic strategies have been developed, such as cell reprogramming, trying to generate more DA in PD treatment. This review mainly discusses the advantages, methodology, cell origin, transformation efficiency, and practical application shortcomings of cell reprogramming therapy in PD strategy.
帕金森病（PD）是一种神经退行性疾病，其特征是黑质致密部多巴胺神经元变性。患者会出现一系列运动症状，如静止性震颤，这会损害他们在日常生活中的自理能力。在疾病后期，患者无法独立行走，长期卧床，生活质量显著下降。到目前为止，帕金森病的治疗方法主要包括药物治疗和深部脑刺激。药物治疗旨在提高多巴胺（DA）水平；然而，治疗效果在短期内更为明显，对疾病的整体进展改善并无益处。近年来，已经开发出了新的治疗策略，如细胞重编程，试图在帕金森病治疗中产生更多的多巴胺。本综述主要讨论了细胞重编程疗法在帕金森病治疗策略中的优势、方法、细胞来源、转化效率以及实际应用中的缺点。
