Hun Marady, Wen Huai, Han Phanna, Vun Tharith, Zhao Mingyi, He Qingnan
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Front Cell Dev Biol. 2023 Jan 5;10:1070516. doi: 10.3389/fcell.2022.1070516. eCollection 2022.
In recent years, there has been an increasing interest in using extracellular vesicles (EVs) as potential therapeutic agents or natural drug delivery systems in kidney-related diseases. However, a detailed and targeted report on the current condition of extracellular vesicle research in kidney-related diseases is lacking. Therefore, this prospective study was designed to investigate the use of bibliometric analysis to comprehensively overview the current state of research and frontier trends on extracellular vesicle research in kidney-related diseases using visualization tools. The Web of Science Core Collection (WoSCC) database was searched to identify publications related to extracellular vesicle research in kidney-related diseases since 1999. Citespace, Microsoft Excel 2019, VOSviewer software, the R Bibliometrix Package, and an online platform were used to analyze related research trends to stratify the publication data and collaborations. From 1 January 1999 to 26 June 2022, a total of 1,122 EV-related articles and reviews were published, and 6,486 authors from 1,432 institutions in 63 countries or regions investigated the role of extracellular vesicles in kidney-related diseases. We found that the number of articles on extracellular vesicles in kidney-related diseases increased every year. Dozens of publications were from China and the United States. China had the most number of related publications, in which the Southeast University (China) was the most active institution in all EV-related fields. Liu Bi-cheng published the most papers on extracellular vesicles, while Clotilde Théry had the most number of co-citations. Most papers were published by The International Journal of Molecular Sciences, while Kidney International was the most co-cited journal for extracellular vesicles. We found that exosome-related keywords included exosome, exosm, expression, extracellular vesicle, microRNA, microvesicle, and liquid biopsy, while disease- and pathological-related keywords included biomarker, microRNA, apoptosis, mechanism, systemic lupus erythematosus, EGFR, acute kidney injury, and chronic kidney disease. Acute kidney disease (AKI), CKD, SLE, exosome, liquid biopsy, and extracellular vesicle were the hotspot in extracellular vesicle and kidney-related diseases research. The field of extracellular vesicles in kidney-related disease research is rapidly growing, and its domain is likely to expand in the next decade. The findings from this comprehensive analysis of extracellular vesicles in kidney-related disease research could help investigators to set new diagnostic, therapeutic, and prognostic ideas or methods in kidney-related diseases.
近年来，人们越来越关注将细胞外囊泡（EVs）用作肾脏相关疾病的潜在治疗剂或天然药物递送系统。然而，目前缺乏关于肾脏相关疾病中细胞外囊泡研究现状的详细且有针对性的报告。因此，本前瞻性研究旨在利用文献计量分析，通过可视化工具全面概述肾脏相关疾病中细胞外囊泡研究的现状和前沿趋势。检索了科学网核心合集（WoSCC）数据库，以识别自1999年以来与肾脏相关疾病中细胞外囊泡研究相关的出版物。使用Citespace、Microsoft Excel 2019、VOSviewer软件、R文献计量学包和一个在线平台来分析相关研究趋势，以对出版数据和合作进行分层。从1999年1月1日至2022年6月26日，共发表了1122篇与EV相关的文章和综述，来自63个国家或地区1432个机构的6486名作者研究了细胞外囊泡在肾脏相关疾病中的作用。我们发现，与肾脏相关疾病中细胞外囊泡相关的文章数量逐年增加。数十篇出版物来自中国和美国。中国的相关出版物数量最多，其中东南大学（中国）是所有与EV相关领域中最活跃的机构。刘必成发表的关于细胞外囊泡的论文最多，而克洛蒂尔德·泰里的共被引次数最多。大多数论文由《国际分子科学杂志》发表，而《国际肾脏病杂志》是细胞外囊泡被引次数最多的期刊。我们发现，与外泌体相关的关键词包括外泌体、外渗、表达、细胞外囊泡、微小RNA、微囊泡和液体活检，而与疾病和病理相关的关键词包括生物标志物、微小RNA、细胞凋亡、机制、系统性红斑狼疮、表皮生长因子受体、急性肾损伤和慢性肾脏病。急性肾疾病（AKI）、慢性肾脏病（CKD）、系统性红斑狼疮（SLE）、外泌体、液体活检和细胞外囊泡是细胞外囊泡与肾脏相关疾病研究的热点。肾脏相关疾病研究中细胞外囊泡领域正在迅速发展，其领域在未来十年可能会扩大。对肾脏相关疾病研究中细胞外囊泡的这一全面分析结果，可能有助于研究人员在肾脏相关疾病中提出新的诊断、治疗和预后思路或方法。
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