Gong Weijun, Meng Xiangqian, Lei Ping, Li Penghao, Li Jing, Zhu Yan
School of Mathematics Kunming University, Kunming University, Kunming 650214, China.
Jinxin Research Institute for Reproductive Medicine and Genetics, Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu 610000, China.
Data Brief. 2025 Feb 18;59:111409. doi: 10.1016/j.dib.2025.111409. eCollection 2025 Apr.
We present transcriptomic data on human granulosa cells, which are essential parts of reproductive biology. These data consisted of single-cell transcriptomic data from 12 biological samples from two developmental stages (germinal vesicle and metaphase I). We evaluated these data by calculating gene expression profiles at different developmental stages and detected differences in gene expression in granulosa cells at the different developmental stages. We further evaluated the transcriptomic data via genomes from gene banks. Thus, these new data demonstrate the feasibility of obtaining reliable transcriptomic data from individual samples at different developmental stages, and provide a framework for systematic transcriptomic studies of granulosa cell development.
我们展示了人类颗粒细胞的转录组数据，这些细胞是生殖生物学的重要组成部分。这些数据包括来自两个发育阶段（生发泡期和减数第一次分裂中期）的12个生物样本的单细胞转录组数据。我们通过计算不同发育阶段的基因表达谱来评估这些数据，并检测了不同发育阶段颗粒细胞中基因表达的差异。我们还通过基因库中的基因组进一步评估了转录组数据。因此，这些新数据证明了从不同发育阶段的单个样本中获取可靠转录组数据的可行性，并为颗粒细胞发育的系统转录组研究提供了一个框架。
