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CD11c在白细胞生物学中的多面独特作用。

Multifaceted, unique role of CD11c in leukocyte biology.

作者信息

Hou Lifei, Koutsogiannaki Sophia, Yuki Koichi

机构信息

Cardiac Anesthesia Division, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, United States.

Department of Anaesthesia and Immunology, Harvard Medical School, Boston, MA, United States.

出版信息

Front Immunol. 2025 Mar 4;16:1556992. doi: 10.3389/fimmu.2025.1556992. eCollection 2025.

DOI:10.3389/fimmu.2025.1556992
PMID:40103815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11913667/
Abstract

CD11c is widely known as a dendritic cell surface marker but its non-dendritic cell expression profiles as well as its functional role have been gradually delineated. As a member of leukocyte-specific β2 integrin family, CD11c forms a heterodimer with CD18. CD11c/CD18 takes different conformations, which dictate its ligand binding. Here we reviewed CD11c current state of art, in comparison to its sister proteins CD11a, CD11b, and CD11d, illustrating its unique feature in leukocyte biology.

摘要

CD11c作为树突状细胞表面标志物广为人知，但其在非树突状细胞中的表达谱及其功能作用已逐渐被阐明。作为白细胞特异性β2整合素家族的一员，CD11c与CD18形成异二聚体。CD11c/CD18具有不同的构象，这决定了其与配体的结合。在这里，我们综述了CD11c的当前研究现状，并将其与其同源蛋白CD11a、CD11b和CD11d进行比较，以阐明其在白细胞生物学中的独特特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/c9af15708ecd/fimmu-16-1556992-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/e4e4361f1099/fimmu-16-1556992-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/10cdd64cdfc4/fimmu-16-1556992-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/c9af15708ecd/fimmu-16-1556992-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/e4e4361f1099/fimmu-16-1556992-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/10cdd64cdfc4/fimmu-16-1556992-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8cc/11913667/c9af15708ecd/fimmu-16-1556992-g003.jpg

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Multifaceted, unique role of CD11c in leukocyte biology.

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[1]
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[2]
Know Your ABCs: Discovery, Differentiation, and Targeting of T-Bet+ B Cells.

Immunol Rev. 2025-3

[3]
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Arthritis Res Ther. 2024-12-19

[4]
Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus.

J Autoimmun. 2024-12

[5]
B cell-intrinsic IFN-γ promotes excessive CD11c age-associated B cell differentiation and compromised germinal center selection in lupus mice.

Cell Immunol. 2024

[6]
Toll-like receptors and integrins crosstalk.

Front Immunol. 2024

[7]
Ligand binding initiates single-molecule integrin conformational activation.

Cell. 2024-6-6

[8]
Integrin CD11c regulates B cell homeostasis.

Front Immunol. 2024

[9]
The transcription factor ZEB2 drives the formation of age-associated B cells.

Science. 2024-1-26

[10]
Neutrophils as potential therapeutic targets for breast cancer.

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