Dejana E, Remuzzi A, Languino L R, Costantini V, Lauri D, Zanetti A, de Gaetano G
Methods Find Exp Clin Pharmacol. 1985 Mar;7(3):153-9.
A rotating probe device was used to quantitate platelet adhesion to rat aorta subendothelial surface. Platelet adhesion increased in relation to the time of exposure to the subendothelial surface, the shear rate, the percentage of hematocrit and the number of platelets in the suspending media. Human umbilical arteries or collagen-coated glass can be used as adhesion surfaces with results similar to those obtained with rat aorta subendothelium. Platelet-rich plasma or washed platelets can be used in this system with comparable results. The test is sensitive to a series of antiaggregating agents and could be used in clinical studies of platelet adhesion defect.
使用旋转探针装置来定量血小板对大鼠主动脉内皮下表面的黏附。血小板黏附量随着暴露于内皮下表面的时间、剪切速率、血细胞比容百分比以及悬浮介质中血小板数量的增加而增加。人脐动脉或胶原包被的玻璃可用作黏附表面，其结果与用大鼠主动脉内皮下层得到的结果相似。富含血小板血浆或洗涤过的血小板可用于该系统，结果相当。该试验对一系列抗聚集剂敏感，可用于血小板黏附缺陷的临床研究。
