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巴基斯坦肝脏网络立场声明 - I,代谢功能障碍相关脂肪性肝病(MASLD)的病例定义、分类、筛查与诊断:基层和二级医疗医生资源

HEPNET Position Statement-I, Case Definition, Classification, Screening & Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Pakistan: A Resource for Primary and Secondary Care Physicians.

作者信息

Ali Bushra, Kamani Lubna, Salim Adnan, Alam Altaf, Zuberi Bader Faiyaz, Farooqi Javed Iqbal, Naqvi Altaf Baqir, Ali Zeeshan, Majid Shahid, Hashmi Zahid Yasin, Choudhry Asad A, Salih Muhammad, Khan Anwar Ahmed, Azam Syed M Zahid, Abbas Zaigham, Siddique Masood, Nawaz Arif Amir

机构信息

Bushra Ali, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan.

Lubna Kamani, Liaquat National Hospital, National Medical Center, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2025 Mar;41(3):929-938. doi: 10.12669/pjms.41.3.10081.


DOI:10.12669/pjms.41.3.10081
PMID:40103882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11911726/
Abstract

The Hep-Net position paper comes at a significant time in the history of Metabolically Associated Fatty Liver Disease (MAFLD) due to the rapid rise in this disease entity in the past decade. Metabolically Associated Fatty Liver Disease, by its very name, encompasses several common metabolic disease entities, top among those being diabetes and obesity. For Pakistan, the situation is serious as it is among the top 10 countries globally regarding the prevalence of obesity and number one in terms of diabetes, with over a quarter of adults affected. There remains slight ambiguity as regards the nomenclature of MAFLD, with western societies preferring to remove the word "fatty" and substitute with `'steatotic" i.e. MASLD. Regardless of names/titles the metabolic nature of the disease and its management remains the same and fortunately, that is something where universal consensus is present. Under the umbrella of Hep-Net, eminent hepatologists from all over Pakistan have pooled their efforts to formulate guidelines that are specifically tailored to the Pakistani population, its specific lifestyle and relevant interventions that are needed to treat fatty/steatotic liver disease. By virtue of its multi-systemic consequences, metabolic fatty liver disease represents the most significant and expensive disease entity, globally. Prevention, through public education and timely intervention in diagnosed cases will serve to avert a healthcare storm that will far outweigh viral hepatitis.

摘要

由于代谢相关脂肪性肝病(MAFLD)在过去十年中迅速增加,Hep-Net立场文件在其历史上的一个重要时刻发布。代谢相关脂肪性肝病,顾名思义,涵盖了几种常见的代谢性疾病实体,其中最主要的是糖尿病和肥胖症。对于巴基斯坦来说,情况很严峻,因为它在全球肥胖症患病率最高的10个国家之列,在糖尿病方面位居第一,超过四分之一的成年人受到影响。关于MAFLD的命名仍存在一些模糊之处,西方社会倾向于去掉“脂肪性”一词,代之以“脂肪变性的”,即MASLD。无论名称如何,该疾病的代谢性质及其管理方法保持不变,幸运的是,这是存在普遍共识的方面。在Hep-Net的框架下,来自巴基斯坦各地的知名肝病学家共同努力,制定专门针对巴基斯坦人群、其特定生活方式以及治疗脂肪性/脂肪变性肝病所需相关干预措施的指南。鉴于其多系统后果,代谢性脂肪肝病是全球最重要且最昂贵的疾病实体。通过公众教育进行预防,并对确诊病例及时干预,将有助于避免一场比病毒性肝炎严重得多的医疗风暴。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3b/11911726/1af95aa66c79/PJMS-41-929-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3b/11911726/18d74addf776/PJMS-41-929-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3b/11911726/1af95aa66c79/PJMS-41-929-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3b/11911726/18d74addf776/PJMS-41-929-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3b/11911726/1af95aa66c79/PJMS-41-929-g002.jpg

相似文献

[1]
HEPNET Position Statement-I, Case Definition, Classification, Screening & Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Pakistan: A Resource for Primary and Secondary Care Physicians.

Pak J Med Sci. 2025-3

[2]
From metabolic dysfunction-associated fatty liver disease to metabolic dysfunction-associated steatotic liver disease: Controversy and consensus.

World J Hepatol. 2023-12-27

[3]
Impact of nomenclature as metabolic associated steatotic liver disease on steatotic liver disease prevalence and screening: a prospective population survey in Asians.

J Gastroenterol Hepatol. 2024-8

[4]
Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Review and Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association.

Diabetes Metab J. 2024-11

[5]
Management of Metabolic-Associated Fatty Liver Disease/Metabolic Dysfunction-Associated Steatotic Liver Disease: From Medication Therapy to Nutritional Interventions.

Nutrients. 2024-7-11

[6]
Non-invasive Scores and Serum Biomarkers for Fatty Liver in the Era of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): A Comprehensive Review From NAFLD to MAFLD and MASLD.

Curr Obes Rep. 2024-9

[7]
Implications of the new nomenclature of steatotic liver disease and definition of metabolic dysfunction-associated steatotic liver disease.

Aliment Pharmacol Ther. 2024-1

[8]
Metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity: An Obesity Medicine Association (OMA) and expert joint perspective 2025.

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[9]
Practice Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease by the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN).

Indian Pediatr. 2024-10-15

[10]
Critical appraisal of metabolic dysfunction-associated steatotic liver disease: Implication of Janus-faced modernity.

Clin Mol Hepatol. 2023-10

本文引用的文献

[1]
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men.

Biol Sex Differ. 2024-5-17

[2]
Current status and future trends of the global burden of MASLD.

Trends Endocrinol Metab. 2024-8

[3]
PAKISTAN SOCIETY OF HEPATOLOGY (PSH) POSITION STATEMENT: RENAMING NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) TO STEATOTIC LIVER DISEASE (SLD), ENDORSEMENT OF NEW MULTI-SOCIETY NOMENCLATURE.

J Ayub Med Coll Abbottabad. 2023

[4]
Machine learning improves the prediction of significant fibrosis in Asian patients with metabolic dysfunction-associated steatotic liver disease - The Gut and Obesity in Asia (GO-ASIA) Study.

Aliment Pharmacol Ther. 2024-3

[5]
Addressing the looming epidemic of metabolic dysfunction-associated steatotic liver disease in Pakistan: A call for action.

Hepatol Forum. 2024-1-16

[6]
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.

J Hepatol. 2023-12

[7]
Furthering research on MAFLD: the APASL Metabolic fAtty lIver DiseasE coNsortium (MAIDEN).

Hepatol Int. 2023-6

[8]
Identifying advanced MAFLD in a cohort of T2DM and clinical features.

Front Endocrinol (Lausanne). 2023

[9]
Metabolic dysfunction associated fatty liver disease: The new nomenclature and its impact.

World J Gastroenterol. 2023-1-21

[10]
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review.

Hepatology. 2023-4-1

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