准分子激光原位角膜磨镶术（LASIK）术后患者脑自发活动的动态变化：一项静息态功能磁共振成像研究
Dynamic changes of spontaneous brain activity in patients after LASIK: a resting-state fMRI study.
作者信息
Zhang Hui, Xu Zi-Song, Hu Jin-Yu, Liu Zhen-Zhe, Zhong Lei, He Liang-Qi, Chen Cheng, Wang Xiao-Yu, Wei Hong, Zeng Yan-Mei, Ling Qian, Chen Xu, Wang Yi-Xin, Shao Yi
机构信息
Nanchang Bright Eye Hospital, Nanchang 330000, Jiangxi Province, China.
Department of Ophthalmology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
出版信息
Int J Ophthalmol. 2025 Mar 18;18(3):487-495. doi: 10.18240/ijo.2025.03.16. eCollection 2025.
AIM
To investigate changes in local brain activity after laser assisted keratomileusis (LASIK) in myopia patients, and further explore whether post-LASIK (POL) patients and healthy controls (HCs) can be distinguished by differences in dynamic amplitude of low-frequency fluctuations (dALFF) in specific brain regions.
METHODS
The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic patients who underwent LASIK and 15 matched healthy controls. This method was selected to calculate the corresponding dALFF values of each participant, to compare dALFF between the groups and to determine whether dALFF distinguishes reliably between myopic patients after LASIK and HCs using the linear support vector machine (SVM) permutation test (5000 repetitions).
RESULTS
dALFF was lower in POL than in HCs at the right precentral gyrus and right insula. Classification accuracy of the SVM was 89.1% (<0.001).
CONCLUSION
The activity of spontaneous neurons in the right precentral gyrus and right insula of myopic patients change significantly after LASIK. SVM can correctly classify POL patients and HCs based on dALFF differences.
目的
研究近视患者接受准分子原位角膜磨镶术（LASIK）后局部脑活动的变化，并进一步探讨是否可以通过特定脑区低频波动动态幅度（dALFF）的差异来区分LASIK术后（POL）患者和健康对照者（HCs）。
方法
收集15例接受LASIK手术的近视患者和15例匹配的健康对照者的静息态功能磁共振成像（rs-fMRI）数据。采用该方法计算每个参与者相应的dALFF值，比较组间dALFF，并使用线性支持向量机（SVM）置换检验（5000次重复）确定dALFF是否能可靠地区分LASIK术后近视患者和HCs。
结果
在右侧中央前回和右侧岛叶，POL患者的dALFF低于HCs。SVM的分类准确率为89.1%（<0.001）。
结论
近视患者接受LASIK术后，右侧中央前回和右侧岛叶的自发神经元活动发生显著变化。SVM可以根据dALFF差异正确区分POL患者和HCs。
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