Zhang Hao, Ma Weihao, Qiang Chunyu, Nie Jiayuan, Ma Ling, Zhang Yawei, Wang Ke
College of Chemistry and Materials Science, Hebei Normal University Shijiazhuang 050023 China
Shijiazhuang Center for Disease Control and Prevention Shijiazhuang 050011 China
RSC Adv. 2025 Mar 17;15(11):8111-8120. doi: 10.1039/d5ra00080g.
In our research, an emerging magnetic covalent organic framework (FeO@SiO-BD-DADB-COF) was formulated through Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), Several parameters affecting the extraction process were refined. Accordingly, a novel method of determining 15 macrolides (MALs) in honey and water was established through the FeO@SiO-BD-DADB-COF as a magnetic solid-phase extraction (MSPE) adsorbent and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). In consequence, the standard curves for the 15 MALs exhibited an exceptional linearity from 0.1 to 200 μg L, and the correlation coefficients ( ) varied from 0.9990 to 0.9999. The recoveries fell between 70.01% and 115.56%, with the relative standard deviations (RSDs) being below 9.93% ( = 5). The detection limits reached 0.001-0.075 μg L with the quantification limits being 0.004-0.228 μg L. Ultimately, the method was excellently applied to the analysis of MALs in honey and water.
在我们的研究中，通过傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）构建了一种新型磁性共价有机框架（FeO@SiO-BD-DADB-COF）。对影响萃取过程的几个参数进行了优化。因此，建立了一种以FeO@SiO-BD-DADB-COF作为磁性固相萃取（MSPE）吸附剂，结合超高效液相色谱-串联质谱（UPLC-MS/MS）测定蜂蜜和水中15种大环内酯类药物（MALs）的新方法。结果，15种MALs的标准曲线在0.1至200μg/L范围内呈现出优异的线性，相关系数（ ）在0.9990至0.9999之间变化。回收率在70.01%至115.56%之间，相对标准偏差（RSDs）低于9.93%（n = 5）。检测限达到0.001 - 0.075μg/L，定量限为0.004 - 0.228μg/L。最终，该方法成功应用于蜂蜜和水中MALs的分析。
