Li Na, Liang Mengnan, Zhang Hao, Hua Zhongxia, Ma Ling, Qi Yanyu, Wang Ke
College of Chemistry and Materials Science, Hebei Normal University Shijiazhuang 050023 China
Shijiazhuang Center for Disease Control and Prevention Shijiazhuang 050011 China
RSC Adv. 2024 Mar 14;14(12):8303-8312. doi: 10.1039/d4ra00247d. eCollection 2024 Mar 6.
The excessive use of quinolones (QNs) has seriously threatened human health. In this study, a novel functionalized magnetic covalent organic framework FeO@SiO@Ah-COF was fabricated with biphenyl-3,3',5,5'-tetracarbaldehyde and hydrazine hydrate (85%) as monomers and was used as a magnetic solid-phase extraction (MSPE) absorbent for the determination of 24 QNs in water and egg samples through ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The extraction parameters of MSPE were optimized, including pH, adsorbent dosage, adsorption time, and eluent type. An effective and rapid detection method was then established, which showed good linearity ( ≥ 0.9990), low limits of detection (0.003-0.036 μg L) and low limits of quantitation (0.008-0.110 μg L) for QNs. The good recoveries of 24 QNs in water and egg samples were in the range of 70.3-106.1% and 70.4-119.7%, respectively, with relative standard deviations lower than 10% ( = 5). As a result, FeO@SiO@Ah-COF is a promising magnetic adsorbent, and the established method was successfully applied for the determination of 24 QNs in water and egg samples.
喹诺酮类药物（QNs）的过度使用严重威胁着人类健康。在本研究中，以联苯 - 3,3',5,5'-四甲醛和水合肼（85%）为单体，制备了一种新型功能化磁性共价有机框架FeO@SiO@Ah-COF，并将其用作磁性固相萃取（MSPE）吸附剂，通过超高效液相色谱 - 串联质谱法（UPLC-MS/MS）测定水和鸡蛋样品中的24种喹诺酮类药物。对MSPE的萃取参数进行了优化，包括pH值、吸附剂用量、吸附时间和洗脱剂类型。然后建立了一种有效且快速的检测方法，该方法对喹诺酮类药物显示出良好的线性（≥0.9990）、低检测限（0.003 - 0.036 μg/L）和低定量限（0.008 - 0.110 μg/L）。水和鸡蛋样品中24种喹诺酮类药物的良好回收率分别在70.3 - 106.1%和70.4 - 119.7%范围内，相对标准偏差低于10%（n = 5）。结果表明，FeO@SiO@Ah-COF是一种有前景的磁性吸附剂，所建立的方法成功应用于水和鸡蛋样品中24种喹诺酮类药物的测定。
