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低体重婴儿肝移植受者中巨肝综合征的预防

Large-for-size syndrome prophylaxis in infant liver recipients with low body mass.

作者信息

Semash Konstantin, Dzhanbekov Timur

机构信息

Department of Mini-Invasive Surgery, National Children's Medical Center, Tashkent 100171, Toshkent, Uzbekistan.

出版信息

World J Transplant. 2025 Mar 18;15(1):99452. doi: 10.5500/wjt.v15.i1.99452.

DOI:10.5500/wjt.v15.i1.99452
PMID:40104200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11612882/
Abstract

Transplantation of the left lateral section (LLS) of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children, with variants of the LLS primarily used in infants. However, the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains significant. This review explores historical developments, various approaches to measuring the required functional liver mass, and techniques to prevent complications associated with large-for-size grafts in infants.

摘要

目前，肝左外侧叶（LLS）移植已成为治疗儿童晚期弥漫性和不可切除局灶性肝病的既定方法，LLS的变体主要用于婴儿。然而，将成人供体移植物的大小与儿童腹部的体积相匹配的手术挑战仍然很大。本文综述探讨了历史发展、测量所需功能性肝质量的各种方法，以及预防婴儿大体积移植物相关并发症的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/6150c329a55a/99452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/226ce4b992f0/99452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/08b5aac7058c/99452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/6150c329a55a/99452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/226ce4b992f0/99452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/08b5aac7058c/99452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e948/11612882/6150c329a55a/99452-g003.jpg

相似文献

1
Large-for-size syndrome prophylaxis in infant liver recipients with low body mass.低体重婴儿肝移植受者中巨肝综合征的预防
World J Transplant. 2025 Mar 18;15(1):99452. doi: 10.5500/wjt.v15.i1.99452.
2
Selection of living donor liver grafts for patients weighing 6kg or less.为体重6千克及以下患者选择活体供肝移植物。
Liver Transpl. 2015 Feb;21(2):233-8. doi: 10.1002/lt.24048. Epub 2015 Jan 12.
3
Alternatives to left lateral sector in paediatric liver transplantation-a systematic review on monosegmental and reduced grafts.小儿肝移植中左外侧叶的替代方案——关于单节段和减体积移植物的系统评价
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Outflow vein venoplasty of left lateral section graft for living donor liver transplantation in infant recipients.为婴儿受体施行活体供肝移植时，对供肝左外侧叶静脉流出道进行静脉成形术。
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3D-reconstruction and heterotopic implantation of reduced size monosegment or left lateral segment grafts in small infants: A new technique in pediatric living donor liver transplantation to overcome large-for-size syndrome.3D 重建及小体积单肝段或左外叶供肝劈离式肝移植在小婴儿中的应用：一种克服大小肝匹配综合征的小儿活体肝移植新技术。
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Advanced preoperative three-dimensional planning decreases the surgical complications of using large-for-size grafts in pediatric living donor liver transplantation.术前的三维精确规划可降低小儿活体肝移植中大体积供肝的手术并发症。
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Optimal graft size in pediatric living donor liver transplantation: How are children different from adults?小儿活体肝移植中的最佳移植物大小：儿童与成人有何不同？
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Pediatric liver transplantation with hyperreduced left lateral segment graft.小儿肝移植采用超减体积左外叶移植物。
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本文引用的文献

1
Liver Graft Machine Perfusion: From History Perspective to Modern Approaches in Transplant Surgery.肝脏移植机械灌注：从历史角度到移植手术的现代方法。
Exp Clin Transplant. 2024 Jul;22(7):497-508. doi: 10.6002/ect.2024.0137.
2
Implementation of a living donor liver transplantation program in the Republic of Uzbekistan: a report of the first 40 cases.乌兹别克斯坦共和国活体肝移植项目的实施：前40例报告。
Clin Transplant Res. 2024 Jun 30;38(2):116-127. doi: 10.4285/ctr.24.0013. Epub 2024 Jun 24.
3
Advances in pediatric liver transplantation from the pediatric surgeon's perspective.
儿科肝移植的进展：从儿科外科医生的角度看。
Pediatr Surg Int. 2023 Aug 25;39(1):253. doi: 10.1007/s00383-023-05533-8.
4
3D Printing Model of Abdominal Cavity of Liver Transplantation Recipient to Prevent Large-for-Size Syndrome.肝移植受者腹腔的3D打印模型预防大体积综合征
Int J Bioprint. 2022 Aug 24;8(4):609. doi: 10.18063/ijb.v8i4.609. eCollection 2022.
5
Biological abdominal wall expansion in pediatric liver recipients after transplantation with large-for-size organs.小儿大体积供肝肝移植受者术后的生物性腹壁扩张
Pediatr Transplant. 2023 Feb;27(1):e14405. doi: 10.1111/petr.14405. Epub 2022 Oct 6.
6
Alternatives to left lateral sector in paediatric liver transplantation-a systematic review on monosegmental and reduced grafts.小儿肝移植中左外侧叶的替代方案——关于单节段和减体积移植物的系统评价
Hepatobiliary Surg Nutr. 2022 Aug;11(4):567-576. doi: 10.21037/hbsn-20-792.
7
A Novel Strategy for Preventing Posttransplant Large-For-Size Syndrome in Adult Liver Transplant Recipients: A Pilot Study.一种预防成人肝移植受者术后体型过大综合征的新策略：一项初步研究。
Transpl Int. 2022 Jan 12;35:10177. doi: 10.3389/ti.2021.10177. eCollection 2021.
8
Delayed sequential abdominal wall closure in pediatric liver transplantation to overcome "large for size" scenarios.小儿肝移植中延迟序贯腹壁关闭术克服“大小肝”问题。
Pediatr Transplant. 2022 Feb;26(1):e14132. doi: 10.1111/petr.14132. Epub 2021 Sep 2.
9
Large for size in pediatrics liver transplant using left lateral segment grafts: A single center experience.小儿肝移植使用左外叶供肝时大小不匹配：单中心经验。
Pediatr Transplant. 2021 Sep;25(6):e14044. doi: 10.1111/petr.14044. Epub 2021 Jun 2.
10
3D-reconstruction and heterotopic implantation of reduced size monosegment or left lateral segment grafts in small infants: A new technique in pediatric living donor liver transplantation to overcome large-for-size syndrome.3D 重建及小体积单肝段或左外叶供肝劈离式肝移植在小婴儿中的应用：一种克服大小肝匹配综合征的小儿活体肝移植新技术。
Surgery. 2021 Aug;170(2):617-622. doi: 10.1016/j.surg.2021.04.015. Epub 2021 May 27.