From images to clinical insights: an educational review on radiomics in lung diseases.

Radiological imaging is a cornerstone in the clinical workup of lung diseases. Radiomics represents a significant advancement in clinical lung imaging, offering a powerful tool to complement traditional qualitative image analysis. Radiomic features are quantitative and computationally describe shape, intensity, texture and wavelet characteristics from medical images that can uncover detailed and often subtle information that goes beyond the visual capabilities of radiological examiners. By extracting this quantitative information, radiomics can provide deep insights into the pathophysiology of lung diseases and support clinical decision-making as well as personalised medicine approaches. In this educational review, we provide a step-by-step guide to radiomics-based medical image analysis, discussing the technical challenges and pitfalls, and outline the potential clinical applications of radiomics in diagnosing, prognosticating and evaluating treatment responses in respiratory medicine.