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生物活性水凝胶微球的最新进展：材料工程策略与生物医学前景

Recent advances in bioactive hydrogel microspheres: Material engineering strategies and biomedical prospects.

作者信息

Yue Junjiang, Liu Zhengbiao, Wang Lu, Wang Miao, Pan Guoqing

机构信息

Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China.

Department of Orthopedics, Suzhou Industrial Park Xinghu Hospital, No. 1 Tingsheng Street, Suzhou, Jiangsu 215000, China.

出版信息

Mater Today Bio. 2025 Feb 25;31:101614. doi: 10.1016/j.mtbio.2025.101614. eCollection 2025 Apr.

DOI:10.1016/j.mtbio.2025.101614
PMID:40104647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11919335/
Abstract

Hydrogel microspheres are a class of hydrophilic polymeric particles in microscale, which has been developed as a new type of functional biomaterials for wide-range biomedical applications in recent years. This review provides a comprehensive overview of the preparation methods for hydrogel microspheres, including droplet microfluidics, electrospray and emulsion was first summarized. At the same time, we analyze the impacts of these methods on the properties of hydrogel microspheres and explore various functionalization strategies for enhancing their bioactivity and expanding their biomedical applications. In addition, we discuss the recent advances and the further prospect of hydrogel microspheres in life science applications, particularly in cell biology research, bioanalysis and detection, as well as tissue repair and regeneration. By synthesizing the latest developments, this review aims to offer valuable insights and strategies for optimizing hydrogel microspheres in diverse application scenarios and inspire future research and practical innovations.

摘要

水凝胶微球是一类微米级的亲水性聚合物颗粒，近年来已发展成为一种新型的功能生物材料，用于广泛的生物医学应用。本文综述首先总结了水凝胶微球的制备方法，包括微滴微流控、电喷雾和乳液法。同时，我们分析了这些方法对水凝胶微球性能的影响，并探索了各种功能化策略，以增强其生物活性并扩大其生物医学应用。此外，我们讨论了水凝胶微球在生命科学应用中的最新进展和进一步前景，特别是在细胞生物学研究、生物分析与检测以及组织修复与再生方面。通过综合最新进展，本综述旨在为在不同应用场景中优化水凝胶微球提供有价值的见解和策略，并激发未来的研究和实际创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/d387728895b0/gr11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/31a2644cb23c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/bd963349e2ec/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/81abc93c3788/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/18cd59fdbc27/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/61510aa3ee27/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/74bc35970b55/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/893706458adc/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/6470cf9a741c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/10d1378ea9e8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/4ec02fb6b901/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b29a/11919335/f8630a0478a7/gr9.jpg
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