Wang L C, Lee T F
Life Sci. 1985 Jul 1;36(26):2539-46. doi: 10.1016/0024-3205(85)90151-1.
The present study investigated the suitability of different substrates on aminophylline (AMPY)-induced thermogenesis in rats during cold exposure. Feeding of distilled water 60 min prior to cold exposure in two-day fasted rats resulted in the lowest total heat production and final body temperature in both saline- and AMPY-treated groups. Feeding of 5 ml Intralipid (2 Kcal/ml), a triglyceride mixture, did not improve thermogenesis beyond the control levels. However, feeding of isocaloric substitutes of sucrose elevated significantly the total thermogenesis by 7.9% and 7.4% and final body temperature by 2.23 and 1.61 degrees C, respectively, in saline- and AMPY-treated groups. The increase in thermogenesis by sucrose is not due to its thermic effect. It is concluded that sucrose, in combination with AMPY, may be of value in improving resistance to cold.
本研究调查了不同底物对冷暴露期间大鼠氨茶碱（AMPY）诱导产热的适宜性。在禁食两天的大鼠冷暴露前60分钟喂食蒸馏水，导致生理盐水处理组和AMPY处理组的总产热量和最终体温最低。喂食5毫升英脱利匹特（2千卡/毫升），一种甘油三酯混合物，产热并未超过对照水平。然而，在生理盐水处理组和AMPY处理组中，喂食等热量的蔗糖替代物分别使总产热量显著提高了7.9%和7.4%，最终体温分别升高了2.23摄氏度和1.61摄氏度。蔗糖产热增加并非因其热效应。结论是，蔗糖与AMPY联合使用可能对提高抗寒能力有价值。
