Balaji Sharan Kumar, Balasundarasekar Bhavani, Khuwaja Waris Muhammad, Dolan Keean Michael, Dong Xintong
Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
JID Innov. 2025 Feb 5;5(3):100354. doi: 10.1016/j.xjidi.2025.100354. eCollection 2025 May.
Antimicrobial peptides (AMPs) are important innate immune molecules at microbe-host interfaces. The biophysical properties of AMPs that facilitate direct killing of microbes have been extensively reviewed. In this article, we focus on how AMPs perform immunomodulatory functions through interaction with host receptors on epithelial, immune, and neuronal cell types. We summarize the current knowledge of known AMPs in the skin, the receptors that respond to AMPs, and the downstream intracellular signaling pathways. In the end, we discuss the roles of AMP signaling systems in skin diseases.
抗菌肽（AMPs）是微生物与宿主界面重要的固有免疫分子。关于抗菌肽促进直接杀灭微生物的生物物理特性已有广泛综述。在本文中，我们聚焦于抗菌肽如何通过与上皮细胞、免疫细胞和神经细胞类型上的宿主受体相互作用来发挥免疫调节功能。我们总结了目前关于皮肤中已知抗菌肽、对抗菌肽作出反应的受体以及下游细胞内信号通路的知识。最后，我们讨论了抗菌肽信号系统在皮肤疾病中的作用。
