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Accelerated hypofractionated chemoradiation followed by stereotactic ablative radiotherapy boost for locally advanced, unresectable non-small cell lung cancer.

作者信息

Weber Urs M, Watson Alexander S, Kavanagh Brian D, Bunn Paul A

机构信息

Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.

出版信息

Transl Cancer Res. 2025 Feb 28;14(2):676-678. doi: 10.21037/tcr-24-1869. Epub 2025 Feb 26.

DOI:10.21037/tcr-24-1869
PMID:40104723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11912038/
Abstract
摘要

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Accelerated hypofractionated chemoradiation followed by stereotactic ablative radiotherapy boost for locally advanced, unresectable non-small cell lung cancer.加速超分割放化疗序贯立体定向消融放疗增敏用于局部晚期、不可切除的非小细胞肺癌
Transl Cancer Res. 2025 Feb 28;14(2):676-678. doi: 10.21037/tcr-24-1869. Epub 2025 Feb 26.
2
Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.加速超分割放化疗序贯立体定向消融放疗治疗局部晚期不可切除非小细胞肺癌：一项非随机对照试验。
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Accelerated Hypofractionated Radiotherapy for Locally Advanced NSCLC: A Systematic Review From the International Association for the Study of Lung Cancer Advanced Radiation Technology Subcommittee.局部晚期非小细胞肺癌的加速超分割放疗：来自国际肺癌研究协会先进放射技术小组委员会的系统评价
J Thorac Oncol. 2025 Jan;20(1):39-51. doi: 10.1016/j.jtho.2024.09.1437. Epub 2024 Sep 28.
4
Concomitant Chemotherapy and Radiotherapy with SBRT Boost for Unresectable Stage III Non-Small Cell Lung Cancer: A Phase I Study.SBRT 推量同期放化疗治疗不可切除 III 期非小细胞肺癌：一项 I 期研究。
J Thorac Oncol. 2017 Nov;12(11):1687-1695. doi: 10.1016/j.jtho.2017.07.036. Epub 2017 Sep 13.
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Accelerated hypofractionated three-dimensional conformal radiation therapy (3 Gy/fraction) combined with concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer: preliminary results of an early terminated phase II trial.加速超分割三维适形放射治疗（3Gy/分次）联合同步化疗治疗不可切除的Ⅲ期非小细胞肺癌患者：一项提前终止的Ⅱ期试验的初步结果
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Dose escalation of accelerated hypofractionated three-dimensional conformal radiotherapy (at 3 Gy/fraction) with concurrent vinorelbine and carboplatin chemotherapy in unresectable stage III non-small-cell lung cancer: a phase I trial.加速超分割三维适形放疗（3 Gy/分次）联合同步长春瑞滨和顺铂化疗治疗不可切除 III 期非小细胞肺癌的剂量递增：一项 I 期试验。
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本文引用的文献

1
Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.加速超分割放化疗序贯立体定向消融放疗治疗局部晚期不可切除非小细胞肺癌：一项非随机对照试验。
JAMA Oncol. 2024 Mar 1;10(3):352-359. doi: 10.1001/jamaoncol.2023.6033.
2
The effective radiation dose to immune cells predicts lymphopenia and inferior cancer control in locally advanced NSCLC.有效辐射剂量对免疫细胞的预测作用，提示其与局部晚期 NSCLC 患者的淋巴细胞减少症及癌症控制不良相关。
Radiother Oncol. 2024 Jan;190:110030. doi: 10.1016/j.radonc.2023.110030. Epub 2023 Nov 24.
3
Patterns of Failure, Low-Volume Relapse, and Subsequent Ablative Management in Locally Advanced Non-Small Cell Lung Cancer Treated With Definitive Chemoradiation and Consolidation Immune Checkpoint Inhibitors.
根治性放化疗和巩固性免疫检查点抑制剂治疗局部晚期非小细胞肺癌的失败模式、低容量复发和随后的消融性管理。
Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1435-1444. doi: 10.1016/j.ijrobp.2023.10.005. Epub 2023 Oct 21.
4
Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.PACIFIC试验的五年生存结果：III期非小细胞肺癌放化疗后使用度伐利尤单抗治疗
J Clin Oncol. 2022 Apr 20;40(12):1301-1311. doi: 10.1200/JCO.21.01308. Epub 2022 Feb 2.
5
Higher Radiation Dose to the Immune Cells Correlates with Worse Tumor Control and Overall Survival in Patients with Stage III NSCLC: A Secondary Analysis of RTOG0617.III期非小细胞肺癌患者中，免疫细胞接受更高辐射剂量与更差的肿瘤控制及总生存期相关：RTOG0617的二次分析
Cancers (Basel). 2021 Dec 8;13(24):6193. doi: 10.3390/cancers13246193.
6
Impact of Radiation Dose to the Host Immune System on Tumor Control and Survival for Stage III Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.根治性放疗治疗 III 期非小细胞肺癌时宿主免疫系统辐射剂量对肿瘤控制和生存的影响。
Int J Radiat Oncol Biol Phys. 2019 Oct 1;105(2):346-355. doi: 10.1016/j.ijrobp.2019.05.064. Epub 2019 Jun 5.
7
Safety and Efficacy of a Five-Fraction Stereotactic Body Radiotherapy Schedule for Centrally Located Non-Small-Cell Lung Cancer: NRG Oncology/RTOG 0813 Trial.一种用于中央型非小细胞肺癌的五分割立体定向体放射治疗方案的安全性和疗效：NRG 肿瘤学/RTOG 0813 试验。
J Clin Oncol. 2019 May 20;37(15):1316-1325. doi: 10.1200/JCO.18.00622. Epub 2019 Apr 3.
8
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.Durvalumab 用于 III 期非小细胞肺癌放化疗后的治疗。
N Engl J Med. 2017 Nov 16;377(20):1919-1929. doi: 10.1056/NEJMoa1709937. Epub 2017 Sep 8.
9
Late-Course Adaptive Adjustment Based on Metabolic Tumor Volume Changes during Radiotherapy May Reduce Radiation Toxicity in Patients with Non-Small Cell Lung Cancer.基于放疗期间代谢肿瘤体积变化的疗程后期适应性调整可能降低非小细胞肺癌患者的放射毒性。
PLoS One. 2017 Jan 26;12(1):e0170901. doi: 10.1371/journal.pone.0170901. eCollection 2017.
10
Using fluorodeoxyglucose positron emission tomography to assess tumor volume during radiotherapy for non-small-cell lung cancer and its potential impact on adaptive dose escalation and normal tissue sparing.使用氟脱氧葡萄糖正电子发射断层扫描评估非小细胞肺癌放疗期间的肿瘤体积及其对适应性剂量递增和正常组织保护的潜在影响。
Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1228-34. doi: 10.1016/j.ijrobp.2008.10.054.