1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子）对豚鼠离体灌流心脏心功能的影响
Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart.
作者信息
Saeki S, Masugi F, Ogihara T, Otsuka A, Kumahara Y, Watanabe K, Tamura K, Akashi A, Kumagai A
出版信息
Life Sci. 1985 Jul 29;37(4):325-9. doi: 10.1016/0024-3205(85)90502-8.
The direct cardiac action of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) was studied in isolated perfused guinea-pig heart preparations. PAF produced a fall in left ventricular pressure, decreases in the rate of rise of the left ventricular pressure (dp/dt) and coronary flow, but had no effect on heart rate. These results indicate that PAF is a cardiodepressant with inotropic selectivity and this effect on heart is blocked by CV-3988, a specific PAF antagonist.
在离体灌流豚鼠心脏标本中研究了1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（PAF）的直接心脏作用。PAF可使左心室压力下降，左心室压力上升速率（dp/dt）及冠脉流量降低，但对心率无影响。这些结果表明PAF是一种具有变力性选择性的心脏抑制药，且PAF对心脏的这种作用可被特异性PAF拮抗剂CV-3988阻断。
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