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本文引用的文献

1
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4.肿瘤微环境中的前列腺素E2：由EP2和EP4受体介导的复杂情况
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.
2
Role of prostaglandin E2 in tissue repair and regeneration.前列腺素 E2 在组织修复和再生中的作用。
Theranostics. 2021 Aug 13;11(18):8836-8854. doi: 10.7150/thno.63396. eCollection 2021.
3
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.15-羟基前列腺素脱氢酶作为癌症化学预防和治疗的新分子靶标。
Biochem Pharmacol. 2011 Nov 15;82(10):1352-60. doi: 10.1016/j.bcp.2011.08.005. Epub 2011 Aug 11.
4
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).15-羟基前列腺素脱氢酶（15-PGDH）的调控。非甾体抗炎药（NSAIDs）。
Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):37-40. doi: 10.1016/j.prostaglandins.2011.06.005. Epub 2011 Jul 6.
5
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions.烟酰胺腺嘌呤二核苷酸（NAD⁺）相关的15-羟基前列腺素脱氢酶：结构与生物学功能
Curr Pharm Des. 2006;12(8):955-62. doi: 10.2174/138161206776055958.
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Mechanisms of disease: Inflammatory mediators and cancer prevention.疾病机制：炎症介质与癌症预防
Nat Clin Pract Oncol. 2005 Apr;2(4):202-10. doi: 10.1038/ncponc0140.

新型5,6-稠合和6,6-稠合双环化合物作为15-前列腺素脱氢酶调节剂

Novel 5,6-Fused and 6,6-Fused Bicyclic Compounds as 15-Prostaglandin Dehydrogenase Modulators.

作者信息

Rong Jian, Liang Steven H

机构信息

Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.

出版信息

ACS Med Chem Lett. 2025 Jan 23;16(3):366-367. doi: 10.1021/acsmedchemlett.5c00010. eCollection 2025 Mar 13.

DOI:10.1021/acsmedchemlett.5c00010
PMID:40104792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11912281/
Abstract

This patent highlight describes novel substituted 5,6-fused and 6,6-fused bicyclic compounds as 15-prostaglandin dehydrogenase (15-PGDH) modulators. It provides a detailed account of their synthesis, pharmaceutical composition, and potential use in the treatment for 15-PGDH-related diseases, such as intestinal, gastrointestinal, or bowel disorders.

摘要

本专利亮点介绍了新型取代的5,6-稠合和6,6-稠合双环化合物作为15-前列腺素脱氢酶（15-PGDH）调节剂。它详细阐述了其合成方法、药物组合物以及在治疗与15-PGDH相关疾病（如肠道、胃肠道或肠道疾病）中的潜在用途。