新型5,6-稠合和6,6-稠合双环化合物作为15-前列腺素脱氢酶调节剂
Novel 5,6-Fused and 6,6-Fused Bicyclic Compounds as 15-Prostaglandin Dehydrogenase Modulators.
作者信息
Rong Jian, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 Jan 23;16(3):366-367. doi: 10.1021/acsmedchemlett.5c00010. eCollection 2025 Mar 13.
Abstract
This patent highlight describes novel substituted 5,6-fused and 6,6-fused bicyclic compounds as 15-prostaglandin dehydrogenase (15-PGDH) modulators. It provides a detailed account of their synthesis, pharmaceutical composition, and potential use in the treatment for 15-PGDH-related diseases, such as intestinal, gastrointestinal, or bowel disorders.
摘要
本专利亮点介绍了新型取代的5,6-稠合和6,6-稠合双环化合物作为15-前列腺素脱氢酶（15-PGDH）调节剂。它详细阐述了其合成方法、药物组合物以及在治疗与15-PGDH相关疾病（如肠道、胃肠道或肠道疾病）中的潜在用途。
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